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Tbio
GUCA2A
Guanylin

Protein Summary
Description
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357001
  • ENSP00000349493
  • ENSG00000197273

Symbol
  • GUCA2
  • GUCA2
  • STARA
  • GCAP-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
gene perturbation
0.63
tissue
0.56
PubMedID
0.48
cell line
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.69   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.69   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
GUCY2C
Tclin
Family:  Kinase
Novelty:  0.00209733
Score:  0.994
Data Source:  Reactome,STRINGDB
NPR3
Tchem
Novelty:  0.00227442
Score:  0.86
Data Source:  STRINGDB
TMIGD1
Tbio
Novelty:  0.21889871
Score:  0.837
Data Source:  STRINGDB
EMD
Tbio
Novelty:  0.00135202
Score:  0.8
Data Source:  STRINGDB
GUCA2B
Tbio
Family:  Enzyme
Novelty:  0.02002363
Score:  0.736
Data Source:  STRINGDB
GUCA1A
Tbio
Family:  Enzyme
Novelty:  0.01003665
Score:  0.728
Data Source:  STRINGDB
CYREN
Tbio
Novelty:  0.00278834
Score:  0.718
Data Source:  STRINGDB
GUCY2D
Tbio
Family:  Kinase
Novelty:  0.00578343
Score:  0.7
Data Source:  STRINGDB
CFTR
Tclin
Family:  IC
Novelty:  0.00012639
Score:  0.681
Data Source:  STRINGDB
CLCA1
Tbio
Family:  IC
Novelty:  0.01111462
Score:  0.676
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (57)
Digestion (R-HSA-8935690)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Digestion
Reactome
Digestion and absorption
Name
Explore in Pharos
Explore in Source
Digestion
Digestion and absorption
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
1
1
2.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
2.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase activator 2A
VGNC:6853
746977
Macaque
guanylate cyclase activator 2A
696455
Mouse
MGI:102738
14915
Rat
RGD:2766
25656
Dog
guanylate cyclase activator 2A
VGNC:41564
482446
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanylate cyclase activator 2A
Macaque
guanylate cyclase activator 2A
Mouse
Rat
Dog
guanylate cyclase activator 2A
Publication Statistics
PubMed Score 105.69
PubMed score by year
PubTator Score 117.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title