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Tchem
GTPBP4
Nucleolar GTP-binding protein 1

Protein Summary
Description
Involved in the biogenesis of the 60S ribosomal subunit. GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360803
  • ENSP00000354040
  • ENSG00000107937

Symbol
  • CRFG
  • NOG1
  • NGB
  • CRFG
  • NOG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
0.95
transcription factor binding site profile
0.9
histone modification site profile
0.89
hub protein
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1371.69   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1371.69   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (467)
CNBP
Tbio
Novelty:  0.00404247
p_int:  0.987452145
p_ni:  0.012547854
Score:  0.728
Data Source:  BioPlex,STRINGDB
RPL11
Tbio
Novelty:  0.00448962
p_int:  0.984747236
p_ni:  0.015252764
Score:  0.575
Data Source:  BioPlex,STRINGDB
H1FOO
Tbio
Novelty:  0.02189067
p_int:  0.971821509
p_ni:  0.028178491
Data Source:  BioPlex
RPL30
Tbio
Novelty:  0.0134194
p_int:  0.966830026
p_ni:  0.033169974
Score:  0.725
Data Source:  BioPlex,STRINGDB
RBM34
Tdark
Novelty:  0.58131282
p_int:  0.964901433
p_ni:  0.035098567
Score:  0.956
Data Source:  BioPlex,STRINGDB
RPL18
Tbio
Novelty:  0.01765545
p_int:  0.962093509
p_ni:  0.037906491
Score:  0.634
Data Source:  BioPlex,STRINGDB
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
p_int:  0.961531015
p_ni:  0.038468985
Score:  0.27
Data Source:  BioPlex,STRINGDB
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.956791393
p_ni:  0.043208607
Data Source:  BioPlex
H1FNT
Tdark
Novelty:  0.05593238
p_int:  0.953756725
p_ni:  0.046243275
Data Source:  BioPlex
SART3
Tbio
Novelty:  0.02353492
p_int:  0.953737084
p_ni:  0.046262916
Score:  0.167
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
2
2
94.8
basophil percentage of leukocytes
2
2
2
94.6
eosinophil count
3
3
3
93.7
creatinine measurement
3
3
4
93.6
glomerular filtration rate
3
3
4
93.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
94.8
basophil percentage of leukocytes
2
94.6
eosinophil count
3
93.7
creatinine measurement
4
93.6
glomerular filtration rate
4
93.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GTP binding protein 4
VGNC:4701
450261
Macaque
GTP binding protein 4
709873
Mouse
MGI:1916487
69237
Rat
RGD:620783
114300
Dog
GTP binding protein 4
VGNC:49777
478021
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GTP binding protein 4
Macaque
GTP binding protein 4
Mouse
Rat
Dog
GTP binding protein 4
Publication Statistics
PubMed Score 1371.69
PubMed score by year
PubTator Score 7.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title