Tbio GTPBP2 GTP-binding protein 2

Protein Summary

Description

GTP-binding proteins, or G proteins, constitute a superfamily capable of binding GTP or GDP. G proteins are activated by binding GTP and are inactivated by hydrolyzing GTP to GDP. This general mechanism enables G proteins to perform a wide range of biologic activities.[supplied by OMIM, Jan 2003]

Uniprot Accession IDs

• Q9BX10
• Q5T7E8
• Q8ND84
• Q8TAH7
• Q8WUA5
• Q9HCS9
• Q9NRU4
• Q9NX60

Gene Name

• GTPBP2

Ensembl ID

• ENST00000307114
• ENSP00000304893
• ENSG00000172432
• ENST00000307126
• ENSP00000303997

Symbol

• JABELS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.98
virus perturbation	0.97
transcription factor perturbation	0.96
molecular function	0.91
transcription factor binding site profile	0.84

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Gtp-binding Protein 2

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Gtp-binding Protein 2

Protein / Hydrolase / Gtp-binding Protein 2

Protein / Enzyme Modulator / G-protein / Gtp-binding Protein 2

DTO Classes

Protein / Enzyme / Hydrolase / Gtp-binding Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.34   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.34   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0