Tbio GTPBP1 GTP-binding protein 1

Protein Summary

Description

Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity). This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mouse, where disruption of the gene for that protein had no observable phenotype. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00178
• Q6IC67
• G-protein 1

Gene Name

• GTPBP1

Ensembl ID

• ENST00000216044
• ENSP00000216044
• ENSG00000100226

Symbol

• GP1
• GP-1
• HSPC018

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
virus perturbation	0.98
molecular function	0.94
protein domain	0.85
transcription factor perturbation	0.8

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Gtp-binding Protein 1

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Gtp-binding Protein 1

Protein / Hydrolase / Gtp-binding Protein 1

Protein / Enzyme Modulator / G-protein / Gtp-binding Protein 1

DTO Classes

Protein / Enzyme / Hydrolase / Gtp-binding Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 969.08   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 175   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 969.08   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0