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Tdark
GTF3C2
General transcription factor 3C polypeptide 2

Protein Summary
Description
Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264720
  • ENSP00000264720
  • ENSG00000115207
  • ENST00000359541
  • ENSP00000352536

Symbol
  • KIAA0011
  • TFIIIC110
  • TFIIIC-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.98
transcription factor perturbation
0.96
transcription factor binding site profile
0.87
histone modification site profile
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.98   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.98   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
GTF3C4
Tdark
Family:  Epigenetic
Novelty:  0.28198123
p_int:  0.999985616
p_ni:  0.000014384
Score:  0.998
Data Source:  BioPlex,STRINGDB
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
p_int:  0.999971024
p_ni:  0.000028976
Score:  0.18
Data Source:  BioPlex,STRINGDB
TRAF3IP1
Tbio
Novelty:  0.0668178
p_int:  0.999915147
p_ni:  0.00008479
p_wrong:  6.4e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
ZNF496
Tbio
Family:  TF
Novelty:  0.18264818
p_int:  0.999580813
p_ni:  0.000418856
p_wrong:  3.32e-7
Score:  0.557
Data Source:  BioPlex,STRINGDB
ZNF638
Tbio
Novelty:  0.13248064
p_int:  0.999087019
p_ni:  0.000912981
Score:  0.354
Data Source:  BioPlex,STRINGDB
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.998624075
p_ni:  0.001375925
Data Source:  BioPlex
ZNF785
Tdark
Family:  TF
Novelty:  0.42629766
p_int:  0.998564889
p_ni:  0.001435111
Data Source:  BioPlex
C1QBP
Tbio
Novelty:  0.00532825
p_int:  0.998211402
p_ni:  0.001788598
Score:  0.499
Data Source:  BioPlex,STRINGDB
GTF3C3
Tdark
Novelty:  0.48547531
p_int:  0.993575775
p_ni:  0.006424225
Score:  0.998
Data Source:  BioPlex,STRINGDB
ZNF579
Tdark
Family:  TF
Novelty:  4.75515836
p_int:  0.9915854
p_ni:  0.008414599
p_wrong:  2e-9
Score:  0.544
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase III Abortive And Retractive Initiation
Reactome
RNA Polymerase III Transcription
Reactome
RNA Polymerase III Transcription Initiation
Reactome
RNA Polymerase III Transcription Initiation From Type 1 Promoter
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription
RNA Polymerase III Transcription Initiation
RNA Polymerase III Transcription Initiation From Type 1 Promoter
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
10
19
31
99.9
C-reactive protein measurement
2
7
7
98.2
total cholesterol measurement
3
6
4
3.9
96.5
serum gamma-glutamyl transferase measurement
1
4
4
96
urate measurement
1
4
4
95.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
31
99.9
C-reactive protein measurement
7
98.2
total cholesterol measurement
4
3.9
96.5
serum gamma-glutamyl transferase measurement
4
96
urate measurement
4
95.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIIC subunit 2
VGNC:2937
459097
Macaque
protein Mpv17 [Source:RefSeq peptide;Acc:NP_001247906]
Mouse
MGI:1919002
71752
Rat
RGD:1560392
313914
Dog
general transcription factor IIIC subunit 2
VGNC:41552
483010
Species
Name
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIIC subunit 2
Macaque
protein Mpv17 [Source:RefSeq peptide;Acc:NP_001247906]
Mouse
Rat
Dog
general transcription factor IIIC subunit 2
Publication Statistics
PubMed Score 4.98
PubMed score by year
PubTator Score 2.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title