Tbio GTF2I General transcription factor II-I

Protein Summary

Description

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• P78347
• O14743
• O15359
• O43546
• O43588
• O43589
• Q75M85
• Q75M86
• Q75M87
• Q75M88
• Q86U51
• Q9BSZ4
• GTFII-I

Gene Name

• GTF2I

Ensembl ID

• ENST00000443166
• ENSP00000404240
• ENSG00000263001
• ENST00000573035
• ENSP00000460070
• ENST00000614986
• ENSP00000484526
• ENST00000620879
• ENSP00000477837
• ENST00000621734
• ENSP00000482476

Symbol

• BAP135
• WBSCR6
• WBS
• DIWS
• SPIN
• IB291
• BAP135
• BTKAP1
• TFII-I
• WBSCR6
• GTFII-I

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
hub protein	0.99
virus perturbation	0.97
kinase	0.94
transcription factor binding site profile	0.93

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.36   (req: < 5)

Gene RIFs: 69   (req: <= 3)

Antibodies: 389   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 182.36   (req: >= 5)

Gene RIFs: 69   (req: > 3)

Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0