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Tbio
GTF2H5
General transcription factor IIH subunit 5

Protein Summary
Description
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell. This gene encodes a subunit of transcription/repair factor TFIIH, which functions in gene transcription and DNA repair. This protei ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000607778
  • ENSP00000476100
  • ENSG00000272047

Symbol
  • C6orf175
  • TTDA
  • TTD
  • TFB5
  • TTD3
  • TTDA
  • TFIIH
  • TTD-A
  • TGF2H5
  • C6orf175
  • bA120J8.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.85
cell type or tissue
0.78
transcription factor perturbation
0.74
kinase perturbation
0.71
tissue sample
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.44   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.44   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (238)
GTF2H3
Tbio
Novelty:  0.08168167
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
ERCC3
Tbio
Family:  Enzyme
Novelty:  0.00978601
p_int:  0.999999998
p_ni:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
GTF2H1
Tbio
Novelty:  0.01736328
p_int:  0.999999967
p_ni:  3.3e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
GTF2H4
Tbio
Novelty:  0.03140561
p_int:  0.999999621
p_ni:  1.64e-7
p_wrong:  2.16e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
GTF2H2
Tbio
Novelty:  0.02761619
p_int:  0.999945636
p_ni:  0.000054304
p_wrong:  6e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
ERCC2
Tchem
Family:  Enzyme
Novelty:  0.00240155
Score:  0.999
Data Source:  STRINGDB
CCNH
Tbio
Novelty:  0.00693072
Score:  0.999
Data Source:  STRINGDB
GTF2B
Tbio
Novelty:  0.00179492
Score:  0.998
Data Source:  STRINGDB
POLR2I
Tbio
Family:  Enzyme
Novelty:  0.03100605
Score:  0.997
Data Source:  STRINGDB
POLR2L
Tbio
Family:  Enzyme
Novelty:  0.03847579
Score:  0.997
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (49)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 47
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Disease
Reactome
Dual Incision in GG-NER
Reactome
Dual incision in TC-NER
Reactome
Epigenetic regulation of gene expression
Name
Explore in Pharos
Explore in Source
DNA Repair
Disease
Dual Incision in GG-NER
Dual incision in TC-NER
Epigenetic regulation of gene expression
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age-related hearing impairment
1
1
0
7.1
55.2
lipoprotein A measurement
1
1
1
39.6
cognitive function measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age-related hearing impairment
0
7.1
55.2
lipoprotein A measurement
1
39.6
cognitive function measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
general transcription factor IIH subunit 5
700107
Mouse
MGI:107227
66467
Rat
RGD:1560991
502227
Dog
general transcription factor IIH subunit 5
VGNC:41549
612182
Cow
general transcription factor IIH subunit 5
VGNC:29698
518046
Species
Name
OMA
EggNOG
Inparanoid
Macaque
general transcription factor IIH subunit 5
Mouse
Rat
Dog
general transcription factor IIH subunit 5
Cow
general transcription factor IIH subunit 5
Publication Statistics
PubMed Score 23.44
PubMed score by year
PubTator Score 40.97
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title