You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GTF2H2
General transcription factor IIH subunit 2

Protein Summary
Description
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter. This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274400
  • ENSP00000274400
  • ENSG00000145736
  • ENST00000330280
  • ENSP00000328901
  • ENST00000612581
  • ENSP00000480548
  • ENSG00000276910
  • ENST00000617228
  • ENSP00000479262
  • ENSG00000275045
  • ENST00000619997
  • ENSP00000477954
  • ENST00000628423
  • ENSP00000486014

Symbol
  • BTF2P44
  • p44
  • BTF2
  • TFIIH
  • BTF2P44
  • T-BTF2P44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
cellular component
0.79
protein domain
0.73
kinase perturbation
0.71
tissue sample
0.66


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.75   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.75   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (233)
GTF2H4
Tbio
Novelty:  0.03140561
p_int:  0.9999955
p_ni:  0.0000045
Score:  0.999
Data Source:  BioPlex,STRINGDB
GTF2H3
Tbio
Novelty:  0.08168167
p_int:  0.999994944
p_ni:  0.000005056
Score:  0.999
Data Source:  BioPlex,STRINGDB
ERCC3
Tbio
Family:  Enzyme
Novelty:  0.00978601
p_int:  0.999966473
p_ni:  0.000033527
Score:  0.999
Data Source:  BioPlex,STRINGDB
GTF2H5
Tbio
Novelty:  0.03493285
p_int:  0.999945636
p_ni:  0.000054304
p_wrong:  6e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
RNF135
Tbio
Family:  Enzyme
Novelty:  0.05600338
p_int:  0.99945877
p_ni:  0.000541228
p_wrong:  2e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.931398224
p_ni:  0.068601699
p_wrong:  7.8e-8
Data Source:  BioPlex
ZNF232
Tdark
Family:  TF
Novelty:  0.68288358
p_int:  0.812027928
p_ni:  0.18797207
p_wrong:  2e-9
Data Source:  BioPlex
GTF2H1
Tbio
Novelty:  0.01736328
Score:  0.999
Data Source:  STRINGDB
ERCC5
Tchem
Family:  Enzyme
Novelty:  0.00819696
Score:  0.999
Data Source:  STRINGDB
CCNH
Tbio
Novelty:  0.00693072
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (53)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 47
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Disease
Reactome
Dual Incision in GG-NER
Reactome
Dual incision in TC-NER
Reactome
Epigenetic regulation of gene expression
Name
Explore in Pharos
Explore in Source
DNA Repair
Disease
Dual Incision in GG-NER
Dual incision in TC-NER
Epigenetic regulation of gene expression
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Non-traceable Author Statement (NAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
42.3
blood protein measurement
1
1
1
42.3
blood protein measurement
1
1
1
42.3
myeloid white cell count
1
1
1
10.1
myeloid white cell count
1
1
1
10.1
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
42.3
blood protein measurement
1
42.3
blood protein measurement
1
42.3
myeloid white cell count
1
10.1
myeloid white cell count
1
10.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
general transcription factor IIH subunit 2
700737
Species
Name
OMA
EggNOG
Inparanoid
Macaque
general transcription factor IIH subunit 2
Publication Statistics
PubMed Score 16.75
PubMed score by year
PubTator Score 85.78
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title