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Tbio
GTF2F2
General transcription factor IIF subunit 2

Protein Summary
Description
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340473
  • ENSP00000340823
  • ENSG00000188342

Symbol
  • RAP30
  • BTF4
  • RAP30
  • TF2F2
  • TFIIF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
histone modification site profile
0.91
kinase perturbation
0.81
transcription factor binding site profile
0.81
cellular component
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.89   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.89   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (394)
CBLN4
Tbio
Novelty:  0.11296355
p_int:  0.999936583
p_ni:  0.000057107
p_wrong:  0.00000631
Score:  0.206
Data Source:  BioPlex,STRINGDB
TMEM184A
Tbio
Novelty:  0.16408207
p_int:  0.999923478
p_ni:  0.000073511
p_wrong:  0.000003011
Score:  0.188
Data Source:  BioPlex,STRINGDB
FAM177A1
Tdark
Novelty:  0.31314275
p_int:  0.977116422
p_ni:  0.000254204
p_wrong:  0.022629374
Score:  0.277
Data Source:  BioPlex,STRINGDB
POLR2I
Tbio
Family:  Enzyme
Novelty:  0.03100605
Score:  0.999
Data Source:  STRINGDB
GTF2B
Tbio
Novelty:  0.00179492
Score:  0.999
Data Source:  Reactome,STRINGDB
POLR2B
Tbio
Family:  Enzyme
Novelty:  0.0012624
Score:  0.999
Data Source:  STRINGDB
POLR2E
Tbio
Family:  Enzyme
Novelty:  0.01817288
Score:  0.999
Data Source:  STRINGDB
GTF2E2
Tbio
Novelty:  0.18033153
Score:  0.999
Data Source:  Reactome,STRINGDB
GTF2F1
Tbio
Novelty:  0.02118098
Score:  0.999
Data Source:  Reactome,STRINGDB
POLR2A
Tbio
Family:  Enzyme
Novelty:  0.00188323
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (62)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

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Find Similar Targets
Items per page:
1 – 5 of 57
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Disease
Diseases of signal transduction
ESR-mediated signaling
Estrogen-dependent gene expression
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
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Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
56.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
56.2
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIF subunit 2
VGNC:8878
741868
Macaque
general transcription factor IIF subunit 2
701668
Mouse
MGI:1915955
68705
Rat
RGD:620772
81674
Horse
general transcription factor IIF subunit 2
VGNC:18638
100050971
Species
Name
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIF subunit 2
Macaque
general transcription factor IIF subunit 2
Mouse
Rat
Horse
general transcription factor IIF subunit 2
Publication Statistics
PubMed Score 41.89
PubMed score by year
PubTator Score 35.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title