You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GTF2E2
Transcription initiation factor IIE subunit beta

Protein Summary
Description
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. The general transcription factor IIE (TFIIE) is part of the RNA polymerase II transcription initiation complex, recruiting TFIIH and being essential for promoter clearance by RNA polymerase II. TFIIE is a heterodimer (and sometimes heterotetramer) of alpha and beta subunits. The protein encoded by this gene represents the beta subunit of TFIIE. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355904
  • ENSP00000348168
  • ENSG00000197265

Symbol
  • TF2E2
  • FE
  • TTD6
  • TF2E2
  • TFIIE-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.95
virus perturbation
0.94
histone modification site profile
0.76
transcription factor binding site profile
0.7


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.69   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.69   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (263)
GTF2E1
Tbio
Novelty:  0.39883299
p_int:  0.999999996
p_ni:  4e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
EIF2A
Tbio
Novelty:  0.08652858
p_int:  0.999991191
p_ni:  0.000008809
Data Source:  BioPlex
SBDS
Tbio
Novelty:  0.00818779
p_int:  0.999976238
p_ni:  0.000023683
p_wrong:  8e-8
Data Source:  BioPlex
OIP5
Tbio
Novelty:  0.02546471
p_int:  0.999975003
p_ni:  0.000024939
p_wrong:  5.8e-8
Data Source:  BioPlex
UBLCP1
Tchem
Family:  Enzyme
Novelty:  0.14438023
p_int:  0.999970167
p_ni:  0.000029139
p_wrong:  6.95e-7
Data Source:  BioPlex
FAM49B
Tbio
Novelty:  0.02928708
p_int:  0.999931176
p_ni:  0.000068781
p_wrong:  4.3e-8
Data Source:  BioPlex
MIS18A
Tbio
Novelty:  0.08143008
p_int:  0.999734232
p_ni:  0.000265723
p_wrong:  4.5e-8
Data Source:  BioPlex
DNAJC2
Tbio
Family:  TF
Novelty:  0.01515066
p_int:  0.999683733
p_ni:  0.000299785
p_wrong:  0.000016482
Score:  0.233
Data Source:  BioPlex,STRINGDB
PHPT1
Tbio
Family:  Enzyme
Novelty:  0.02128852
p_int:  0.999650368
p_ni:  0.00004831
p_wrong:  0.000301321
Score:  0.188
Data Source:  BioPlex,STRINGDB
SLK
Tchem
Family:  Kinase
Novelty:  0.00310721
p_int:  0.999181301
p_ni:  0.000818484
p_wrong:  2.15e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
HIV Infection
Reactome
HIV Life Cycle
Reactome
HIV Transcription Initiation
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
HIV Infection
HIV Life Cycle
HIV Transcription Initiation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
17.8
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIE subunit 2
VGNC:6675
464098
Macaque
general transcription factor IIE subunit 2
694622
Mouse
MGI:1915403
68153
Rat
RGD:1310134
306516
Dog
general transcription factor IIE subunit 2
VGNC:41545
100855770
Species
Name
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIE subunit 2
Macaque
general transcription factor IIE subunit 2
Mouse
Rat
Dog
general transcription factor IIE subunit 2
Publication Statistics
PubMed Score 4.69
PubMed score by year
PubTator Score 13.73
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title