You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GTF2E1
General transcription factor IIE subunit 1

Protein Summary
Description
Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283875
  • ENSP00000283875
  • ENSG00000153767

Symbol
  • TF2E1
  • FE
  • TF2E1
  • TFIIE-A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
kinase perturbation
0.88
protein domain
0.85
virus perturbation
0.83
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.85   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.85   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (210)
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.999999996
p_ni:  4e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
SLC45A2
Tbio
Family:  Transporter
Novelty:  0.00268252
p_int:  0.798502479
p_ni:  0.200496194
p_wrong:  0.001001327
Score:  0.297
Data Source:  BioPlex,STRINGDB
ERCC3
Tbio
Family:  Enzyme
Novelty:  0.00978601
Score:  0.999
Data Source:  Reactome,STRINGDB
GTF2H4
Tbio
Novelty:  0.03140561
Score:  0.999
Data Source:  STRINGDB
POLR2A
Tbio
Family:  Enzyme
Novelty:  0.00188323
Score:  0.999
Data Source:  STRINGDB
GTF2F1
Tbio
Novelty:  0.02118098
Score:  0.999
Data Source:  Reactome,STRINGDB
GTF2B
Tbio
Novelty:  0.00179492
Score:  0.999
Data Source:  Reactome,STRINGDB
GTF2F2
Tbio
Novelty:  0.02446629
Score:  0.999
Data Source:  Reactome,STRINGDB
TBP
Tbio
Novelty:  0.00034941
Score:  0.998
Data Source:  STRINGDB
POLR2E
Tbio
Family:  Enzyme
Novelty:  0.01817288
Score:  0.997
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Gene expression (Transcription)
Reactome
HIV Infection
Reactome
HIV Life Cycle
Reactome
HIV Transcription Initiation
Name
Explore in Pharos
Explore in Source
Disease
Gene expression (Transcription)
HIV Infection
HIV Life Cycle
HIV Transcription Initiation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIE subunit 1
VGNC:11976
460615
Macaque
general transcription factor IIE subunit 1
713562
Mouse
MGI:1921447
74197
Rat
RGD:1306851
303918
Dog
general transcription factor IIE subunit 1
VGNC:41544
488002
Species
Name
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIE subunit 1
Macaque
general transcription factor IIE subunit 1
Mouse
Rat
Dog
general transcription factor IIE subunit 1
Publication Statistics
PubMed Score 2.85
PubMed score by year
PubTator Score 12.88
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title