Tbio GTF2A2 Transcription initiation factor IIA subunit 2

Protein Summary

Description

TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• P52657
• A8MYQ7
• Q6FGB5

Gene Name

• GTF2A2

Ensembl ID

• ENST00000396060
• ENSP00000379372
• ENSG00000140307
• ENST00000396061
• ENSP00000379373
• ENST00000396063
• ENSP00000379375

Symbol

• TF2A2
• TF2A2
• TFIIA
• T18745
• TFIIAS
• HsT18745
• TFIIA-12
• TFIIA-gamma

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
virus perturbation	0.98
co-expressed gene	0.95
kinase perturbation	0.84
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Initiation Factor Iia Subunit 2

DTO Classes

Protein / Transcription Factor / Transcription Initiation Factor Iia Subunit 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.48   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 87   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.48   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (195)

Explore Interacting Targets

1 – 10 of 195

• See Interactions on String-DB

TBPL1

Tbio

Novelty:  0.02184575

p_int:  0.999999997

p_ni:  3e-9

Score:  0.894

Data Source:  BioPlex,STRINGDB

CUEDC2

Tbio

Novelty:  0.07403123

p_int:  0.999979514

p_ni:  0.00001477

p_wrong:  0.000005716

Data Source:  BioPlex

S100P

Tbio

Novelty:  0.03293676

p_int:  0.999856888

p_ni:  0.000143112

Data Source:  BioPlex

GTF2A1

Tchem

Novelty:  0.19577296

p_int:  0.999632837

p_ni:  0.000009447

p_wrong:  0.000357716

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

PCBP4

Tbio

Novelty:  0.03763262

p_int:  0.989976642

p_ni:  0.010023353

p_wrong:  5e-9

Data Source:  BioPlex

TBP

Tbio

Novelty:  0.00034941

Score:  0.999

Data Source:  Reactome,STRINGDB

POLR2A

Tbio

Family:  Enzyme

Novelty:  0.00188323

Score:  0.998

Data Source:  STRINGDB

POLR2L

Tbio

Family:  Enzyme

Novelty:  0.03847579

Score:  0.998

Data Source:  STRINGDB

GTF2B

Tbio

Novelty:  0.00179492

Score:  0.998

Data Source:  Reactome,STRINGDB

GTF2E1

Tbio

Novelty:  0.39883299

Score:  0.997

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (28)

Reactome (20)

KEGG (2)

PathwayCommons (2)

WikiPathways (4)

Disease (R-HSA-1643685)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	ESR-mediated signaling	189 targets	R-HSA-8939211
Reactome	Estrogen-dependent gene expression	119 targets	R-HSA-9018519
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	HIV Infection	256 targets	R-HSA-162906

Name	Explore in Pharos	Explore in Source
Disease	1105 targets	R-HSA-1643685
ESR-mediated signaling	189 targets	R-HSA-8939211
Estrogen-dependent gene expression	119 targets	R-HSA-9018519
Gene expression (Transcription)	1452 targets	R-HSA-74160
HIV Infection	256 targets	R-HSA-162906

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (17)

Functions (6)

Components (4)

Processes (7)

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1 – 6 of 6

GO Term	Evidence	Assigned by
transcription coactivator activity	Inferred from Direct Assay (IDA)	BHF-UCL
protein heterodimerization activity	Inferred from Physical Interaction (IPI)	BHF-UCL
protein homodimerization activity	Inferred from Physical Interaction (IPI)	BHF-UCL
TBP-class protein binding	Inferred from Physical Interaction (IPI)	BHF-UCL
transcription factor binding	Inferred from Physical Interaction (IPI)	BHF-UCL
RNA polymerase II repressing transcription factor binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	3	2	3		76.7
neutrophil percentage of leukocytes	EFO_0007990	1	1	1		4.6
lymphocyte percentage of leukocytes	EFO_0007993	1	1	1		2.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	3		76.7
neutrophil percentage of leukocytes	EFO_0007990	1		4.6
lymphocyte percentage of leukocytes	EFO_0007993	1		2.6

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UniProt Keyword Find Similar Targets

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3D-structure
Complete proteome
Host-virus interaction
Nucleus
Reference proteome
Transcription
Transcription regulation

GWAS Trait Find Similar Targets

No Header	No Header
lymphocyte percentage of leukocytes
neutrophil percentage of leukocytes
sex hormone-binding globulin measurement

IDG Resources

No IDG generated resources found

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	general transcription factor IIA subunit 2	VGNC:10169	453483
Macaque	general transcription factor IIA subunit 2		702984
Mouse	general transcription factor II A, 2	MGI:1933289	235459
Rat	general transcription factor 2A subunit 2	RGD:620720	83828
Dog	general transcription factor IIA subunit 2	VGNC:41542	478327

Species	Name	OMA	EggNOG	Inparanoid
Chimp	general transcription factor IIA subunit 2
Macaque	general transcription factor IIA subunit 2
Mouse	general transcription factor II A, 2
Rat	general transcription factor 2A subunit 2
Dog	general transcription factor IIA subunit 2

Publication Statistics

PubMed Score 33.48

PubMed score by year

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PubTator Score 12.43

PubTator score by year

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Related Publications

Text Mined References (31)

GeneRif Annotations (3)

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PMID	Year	Title