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Tbio
GTF2A2
Transcription initiation factor IIA subunit 2

Protein Summary
Description
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by G ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396060
  • ENSP00000379372
  • ENSG00000140307
  • ENST00000396061
  • ENSP00000379373
  • ENST00000396063
  • ENSP00000379375

Symbol
  • TF2A2
  • TF2A2
  • TFIIA
  • T18745
  • TFIIAS
  • HsT18745
  • TFIIA-12
  • TFIIA-gamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
0.98
co-expressed gene
0.95
kinase perturbation
0.84
protein domain
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.48   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.48   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (195)
TBPL1
Tbio
Novelty:  0.02184575
p_int:  0.999999997
p_ni:  3e-9
Score:  0.894
Data Source:  BioPlex,STRINGDB
CUEDC2
Tbio
Novelty:  0.07403123
p_int:  0.999979514
p_ni:  0.00001477
p_wrong:  0.000005716
Data Source:  BioPlex
S100P
Tbio
Novelty:  0.03293676
p_int:  0.999856888
p_ni:  0.000143112
Data Source:  BioPlex
GTF2A1
Tchem
Novelty:  0.19577296
p_int:  0.999632837
p_ni:  0.000009447
p_wrong:  0.000357716
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PCBP4
Tbio
Novelty:  0.03763262
p_int:  0.989976642
p_ni:  0.010023353
p_wrong:  5e-9
Data Source:  BioPlex
TBP
Tbio
Novelty:  0.00034941
Score:  0.999
Data Source:  Reactome,STRINGDB
POLR2A
Tbio
Family:  Enzyme
Novelty:  0.00188323
Score:  0.998
Data Source:  STRINGDB
POLR2L
Tbio
Family:  Enzyme
Novelty:  0.03847579
Score:  0.998
Data Source:  STRINGDB
GTF2B
Tbio
Novelty:  0.00179492
Score:  0.998
Data Source:  Reactome,STRINGDB
GTF2E1
Tbio
Novelty:  0.39883299
Score:  0.997
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (28)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Gene expression (Transcription)
Reactome
HIV Infection
Name
Explore in Pharos
Explore in Source
Disease
ESR-mediated signaling
Estrogen-dependent gene expression
Gene expression (Transcription)
HIV Infection
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
76.7
neutrophil percentage of leukocytes
1
1
1
4.6
lymphocyte percentage of leukocytes
1
1
1
2.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
76.7
neutrophil percentage of leukocytes
1
4.6
lymphocyte percentage of leukocytes
1
2.6
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIA subunit 2
VGNC:10169
453483
Macaque
general transcription factor IIA subunit 2
702984
Mouse
MGI:1933289
235459
Rat
RGD:620720
83828
Dog
general transcription factor IIA subunit 2
VGNC:41542
478327
Species
Name
OMA
EggNOG
Inparanoid
Chimp
general transcription factor IIA subunit 2
Macaque
general transcription factor IIA subunit 2
Mouse
Rat
Dog
general transcription factor IIA subunit 2
Publication Statistics
PubMed Score 33.48
PubMed score by year
PubTator Score 12.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title