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Tchem
GTF2A1
Transcription initiation factor IIA subunit 1

Protein Summary
Description
TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000434192
  • ENSP00000409492
  • ENSG00000165417
  • ENST00000553612
  • ENSP00000452454

Symbol
  • TF2A1
  • TF2A1
  • TFIIA
  • TFIIAL
  • TFIIA-42
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
transcription factor binding site profile
0.94
virus perturbation
0.88
ligand (protein) perturbation
0.83
transcription factor
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.84   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 293   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.84   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (199)
TBPL1
Tbio
Novelty:  0.02184575
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
CYBC1
Tdark
Novelty:  0.72567331
p_int:  0.999927929
p_ni:  0.000072045
p_wrong:  2.7e-8
Score:  0.29
Data Source:  BioPlex,STRINGDB
GTF2A2
Tbio
Novelty:  0.03391028
p_int:  0.999632837
p_ni:  0.000009447
p_wrong:  0.000357716
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
p_int:  0.998709922
p_ni:  0.001290077
p_wrong:  1e-9
Score:  0.193
Data Source:  BioPlex,STRINGDB
TBP
Tbio
Novelty:  0.00034941
p_int:  0.995982218
p_ni:  0.004017782
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PTCD2
Tdark
Novelty:  0.23529342
p_int:  0.991264691
p_ni:  0.008735309
Score:  0.211
Data Source:  BioPlex,STRINGDB
BCAT1
Tchem
Family:  Enzyme
Novelty:  0.00616446
p_int:  0.880485969
p_ni:  0.119514029
p_wrong:  1e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
GTF2B
Tbio
Novelty:  0.00179492
Score:  0.999
Data Source:  Reactome,STRINGDB
POLR2A
Tbio
Family:  Enzyme
Novelty:  0.00188323
Score:  0.998
Data Source:  STRINGDB
ERCC3
Tbio
Family:  Enzyme
Novelty:  0.00978601
Score:  0.997
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Gene expression (Transcription)
Reactome
HIV Infection
Name
Explore in Pharos
Explore in Source
Disease
ESR-mediated signaling
Estrogen-dependent gene expression
Gene expression (Transcription)
HIV Infection
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
79.8
myeloid white cell count
1
1
1
69.8
leukocyte count
1
1
1
64
high density lipoprotein cholesterol measurement
2
2
2
59.9
apolipoprotein A 1 measurement
1
1
1
17.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
79.8
myeloid white cell count
1
69.8
leukocyte count
1
64
high density lipoprotein cholesterol measurement
2
59.9
apolipoprotein A 1 measurement
1
17.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
general transcription factor IIA subunit 1
708130
Mouse
MGI:1933277
83602
Rat
RGD:69246
83830
Dog
general transcription factor IIA subunit 1
VGNC:41541
613006
Horse
general transcription factor IIA subunit 1
VGNC:18632
100059967
Species
Name
OMA
EggNOG
Inparanoid
Macaque
general transcription factor IIA subunit 1
Mouse
Rat
Dog
general transcription factor IIA subunit 1
Horse
general transcription factor IIA subunit 1
Publication Statistics
PubMed Score 4.84
PubMed score by year
PubTator Score 78.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title