Tbio GSTO2 Glutathione S-transferase omega-2

Protein Summary

Description

Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

Uniprot Accession IDs

• Q9H4Y5
• A8K771
• B4DJW6
• E7ESD6
• Q49TW5
• Q5GM70
• Q5JU15
• Q86WP3
• GSTO-2

Gene Name

• GSTO2

Ensembl ID

• ENST00000338595
• ENSP00000345023
• ENSG00000065621
• ENST00000369707
• ENSP00000358721
• ENST00000450629
• ENSP00000390986

Symbol

• GSTO 2-2
• bA127L20.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.82
cell type or tissue	0.74
gene perturbation	0.74
molecular function	0.63
transcription factor	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.73   (req: < 5)

Gene RIFs: 57   (req: <= 3)

Antibodies: 264   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.73   (req: >= 5)

Gene RIFs: 57   (req: > 3)

Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0