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Tbio
GSTM3
Glutathione S-transferase Mu 3

Protein Summary
Description
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers. Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's suscepti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256594
  • ENSP00000256594
  • ENSG00000134202
  • ENST00000361066
  • ENSP00000354357

Symbol
  • GST5
  • GST5
  • GSTB
  • GTM3
  • GSTM3-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
disease perturbation
0.9
disease
0.84
PubMedID
0.8
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.49   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.49   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
GSTM4
Tbio
Family:  Enzyme
Novelty:  0.03845761
p_int:  0.999999973
p_ni:  2.7e-8
Score:  0.952
Data Source:  BioPlex,STRINGDB
GSTM2
Tchem
Family:  Enzyme
Novelty:  0.00334543
p_int:  0.999999877
p_ni:  1.23e-7
Score:  0.99
Data Source:  BioPlex,STRINGDB
GSTM5
Tbio
Family:  Enzyme
Novelty:  0.03763535
p_int:  0.999993572
p_ni:  0.000006428
Score:  0.939
Data Source:  BioPlex,STRINGDB
PPP1R13B
Tbio
Novelty:  0.03903985
p_int:  0.999977834
p_ni:  0.000006629
p_wrong:  0.000015537
Score:  0.189
Data Source:  BioPlex,STRINGDB
HNRNPLL
Tbio
Novelty:  0.0498467
p_int:  0.989563072
p_ni:  0.010372267
p_wrong:  0.000064661
Score:  0.207
Data Source:  BioPlex,STRINGDB
SLBP
Tbio
Novelty:  0.00685735
p_int:  0.989009236
p_ni:  0.000034424
p_wrong:  0.01095634
Score:  0.237
Data Source:  BioPlex,STRINGDB
TPX2
Tbio
Novelty:  0.00435921
p_int:  0.98469571
p_ni:  0.01530429
Score:  0.228
Data Source:  BioPlex,STRINGDB
PLS1
Tbio
Novelty:  0.00538817
p_int:  0.973184091
p_ni:  0.026815885
p_wrong:  2.3e-8
Data Source:  BioPlex
FAM120B
Tbio
Novelty:  0.07982799
p_int:  0.908322482
p_ni:  0.00870225
p_wrong:  0.082975269
Score:  0.237
Data Source:  BioPlex,STRINGDB
LANCL2
Tchem
Novelty:  0.06086418
p_int:  0.87661599
p_ni:  0.034794856
p_wrong:  0.088589154
Score:  0.261
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
Pathways (26)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glutathione conjugation
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
2
2
93.6
high density lipoprotein cholesterol measurement
1
2
2
92.7
apolipoprotein B measurement
2
4
4
90.6
sex hormone-binding globulin measurement
6
1
6
84
2
2
0
1.8
83.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
2
93.6
high density lipoprotein cholesterol measurement
2
92.7
apolipoprotein B measurement
4
90.6
sex hormone-binding globulin measurement
6
84
0
1.8
83.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutathione S-transferase mu 3
VGNC:14255
457128
Macaque
glutathione S-transferase mu 3
700303
Mouse
MGI:1309466
14866
Rat
RGD:61964
64352
Horse
glutathione S-transferase mu 3
VGNC:18627
100061826
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutathione S-transferase mu 3
Macaque
glutathione S-transferase mu 3
Mouse
Rat
Horse
glutathione S-transferase mu 3
Publication Statistics
PubMed Score 128.49
PubMed score by year
PubTator Score 86.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title