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Tbio
GSTA2
Glutathione S-transferase A2

Protein Summary
Description
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutath ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000493422
  • ENSP00000420168
  • ENSG00000244067

Symbol
  • GST2
  • GST2
  • GTA2
  • GTH2
  • GSTA2-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.92
disease
0.83
protein domain
0.73
phenotype
0.7
PubMedID
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.61   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.61   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
GSTA5
Tbio
Family:  Enzyme
Novelty:  0.0799119
p_int:  1
Score:  0.979
Data Source:  BioPlex,STRINGDB
GSTA3
Tbio
Family:  Enzyme
Novelty:  0.02008269
p_int:  0.999999997
p_ni:  3e-9
Score:  0.875
Data Source:  BioPlex,STRINGDB
GSTA4
Tbio
Family:  Enzyme
Novelty:  0.01099229
p_int:  0.999999933
p_ni:  6.5e-8
p_wrong:  2e-9
Score:  0.886
Data Source:  BioPlex,STRINGDB
ATG4C
Tbio
Family:  Enzyme
Novelty:  0.04175533
p_int:  0.981118242
p_ni:  0.000038679
p_wrong:  0.018843079
Score:  0.299
Data Source:  BioPlex,STRINGDB
NUSAP1
Tbio
Novelty:  0.01702118
p_int:  0.961386568
p_ni:  0.034622113
p_wrong:  0.003991319
Score:  0.232
Data Source:  BioPlex,STRINGDB
GSTA1
Tchem
Family:  Enzyme
Novelty:  0.00308319
Score:  0.985
Data Source:  Reactome,STRINGDB
NFE2L2
Tchem
Family:  TF
Novelty:  0.00043828
Score:  0.951
Data Source:  STRINGDB
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.918
Data Source:  STRINGDB
FOS
Tbio
Family:  TF
Novelty:  0.00006103
Score:  0.908
Data Source:  STRINGDB
CREB1
Tbio
Family:  TF
Novelty:  0.00018059
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
Pathways (50)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytokine Signaling in Immune system
Reactome
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Reactome
Glutathione conjugation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytokine Signaling in Immune system
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Glutathione conjugation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
3
3
94.2
platelet count
4
4
4
92
triglyceride measurement
4
3
4
85.3
platelet crit
2
2
2
83.7
red blood cell distribution width
2
2
2
82.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
94.2
platelet count
4
92
triglyceride measurement
4
85.3
platelet crit
2
83.7
red blood cell distribution width
2
82.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 80.61
PubMed score by year
PubTator Score 64.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text