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Tchem
GSTA1
Glutathione S-transferase A1

Protein Summary
Description
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334575
  • ENSP00000335620
  • ENSG00000243955

Symbol
  • GST2
  • GTH1
  • GSTA1-1
  • GST-epsilon
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.99
phenotype
0.98
disease
0.96
biological term
0.85
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.16   (req: < 5)
Gene RIFs: 125   (req: <= 3)
Antibodies: 453   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 355.16   (req: >= 5)
Gene RIFs: 125   (req: > 3)
Antibodies: 453   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (11)
CHEMBL379437
Rendered image for CHEMBL379437
CHEMBL209755
Rendered image for CHEMBL209755
CHEMBL216505
Rendered image for CHEMBL216505
CHEMBL211916
Rendered image for CHEMBL211916
CHEMBL212685
Rendered image for CHEMBL212685
CHEMBL212097
Rendered image for CHEMBL212097
CHEMBL211727
Rendered image for CHEMBL211727
CHEMBL3310889
Rendered image for CHEMBL3310889
Protein-Protein Interactions (96)
GSTA3
Tbio
Family:  Enzyme
Novelty:  0.02008269
p_int:  1
Score:  0.872
Data Source:  BioPlex,STRINGDB
GSTA4
Tbio
Family:  Enzyme
Novelty:  0.01099229
p_int:  0.99999953
p_ni:  1.07e-7
p_wrong:  3.63e-7
Score:  0.837
Data Source:  BioPlex,STRINGDB
SPDL1
Tbio
Novelty:  0.01399644
p_int:  0.98677206
p_ni:  0.01322794
Score:  0.222
Data Source:  BioPlex,STRINGDB
GAR1
Tbio
Novelty:  0.26091307
p_int:  0.974632168
p_ni:  0.018340844
p_wrong:  0.007026987
Score:  0.183
Data Source:  BioPlex,STRINGDB
ZBTB21
Tbio
Family:  TF
Novelty:  0.16032292
p_int:  0.884212563
p_ni:  0.014301273
p_wrong:  0.101486164
Score:  0.301
Data Source:  BioPlex,STRINGDB
GGTLC1
Tbio
Family:  Enzyme
Novelty:  0.10563259
p_int:  0.781994966
p_ni:  0.217998308
p_wrong:  0.000006726
Score:  0.534
Data Source:  BioPlex,STRINGDB
GSTA2
Tbio
Family:  Enzyme
Novelty:  0.01131783
Score:  0.985
Data Source:  Reactome,STRINGDB
GGH
Tchem
Family:  Enzyme
Novelty:  0.00258239
Score:  0.903
Data Source:  STRINGDB
GSTA5
Tbio
Family:  Enzyme
Novelty:  0.0799119
Score:  0.883
Data Source:  STRINGDB
GSTT2B
Tbio
Family:  Enzyme
Novelty:  0.02334158
Score:  0.876
Data Source:  STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
Pathways (21)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glutathione conjugation
Metabolism
Phase II - Conjugation of compounds
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
5
4
5
90.3
hemoglobin measurement
4
4
4
87.2
platelet count
6
6
6
87
glomerular filtration rate
6
2
6
81.9
platelet crit
2
2
2
74.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
5
90.3
hemoglobin measurement
4
87.2
platelet count
6
87
glomerular filtration rate
6
81.9
platelet crit
2
74.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 355.16
PubMed score by year
PubTator Score 259.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text