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Tbio
GSS
Glutathione synthetase

Protein Summary
Description
Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216951
  • ENSP00000216951
  • ENSG00000100983
  • ENST00000451957
  • ENSP00000407517
  • ENST00000643188
  • ENSP00000493903
  • ENST00000644793
  • ENSP00000495750
  • ENST00000646735
  • ENSP00000493763

Symbol
  • GSHS
  • HEL-S-64p
  • HEL-S-88n
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
disease perturbation
0.98
kinase perturbation
0.98
transcription factor perturbation
0.96
histone modification site profile
0.91


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.75   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 368   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.75   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 368   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0