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Tchem
GSPT2
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

Protein Summary
Description
Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.[provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340438
  • ENSP00000341247
  • ENSG00000189369

Symbol
  • ERF3B
  • GST2
  • ERF3B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
protein domain
0.92
gene perturbation
0.71
tissue
0.62
cell type or tissue
0.61


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.17   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.17   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (270)
GSPT1
Tbio
Family:  Enzyme
Novelty:  0.02545195
p_int:  0.999999993
p_ni:  7e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
SRSF12
Tbio
Novelty:  0.34992606
p_int:  0.999571827
p_ni:  0.000427896
p_wrong:  2.77e-7
Score:  0.722
Data Source:  BioPlex,STRINGDB
ETF1
Tbio
Family:  Enzyme
Novelty:  0.00711627
p_int:  0.999147485
p_ni:  0.000852515
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
NCBP3
Tbio
Novelty:  0.07581882
p_int:  0.99809148
p_ni:  0.00190852
Score:  0.256
Data Source:  BioPlex,STRINGDB
PABPC4L
Tdark
Novelty:  0.94386609
p_int:  0.9967952
p_ni:  0.001539545
p_wrong:  0.001665255
Score:  0.684
Data Source:  BioPlex,STRINGDB
CLK3
Tchem
Family:  Kinase
Novelty:  0.03466191
p_int:  0.994054065
p_ni:  0.005945844
p_wrong:  9.1e-8
Score:  0.498
Data Source:  BioPlex,STRINGDB
LARP1B
Tdark
Novelty:  0.22215724
p_int:  0.99267386
p_ni:  0.00732614
Score:  0.348
Data Source:  BioPlex,STRINGDB
CASC3
Tbio
Novelty:  0.03935581
p_int:  0.992365325
p_ni:  0.007634658
p_wrong:  1.7e-8
Score:  0.916
Data Source:  BioPlex,STRINGDB
PABPC4
Tbio
Novelty:  0.06854984
p_int:  0.989132121
p_ni:  0.010867879
Score:  0.889
Data Source:  BioPlex,STRINGDB
PABPC1
Tbio
Novelty:  0.00197523
p_int:  0.986080615
p_ni:  0.013919385
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Eukaryotic Translation Termination
Reactome
Metabolism of RNA
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Eukaryotic Translation Termination
Metabolism of RNA
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
G1 to S phase transition 2 [Source:HGNC Symbol;Acc:HGNC:4622]
Mouse
MGI:1316727
14853
Horse
G1 to S phase transition 2
VGNC:18623
100060648
Zebrafish
ZDB-GENE-030131-4009
325284
S.cerevisiae
S000002579
851752
Species
Name
OMA
EggNOG
Inparanoid
Macaque
G1 to S phase transition 2 [Source:HGNC Symbol;Acc:HGNC:4622]
Mouse
Horse
G1 to S phase transition 2
Zebrafish
S.cerevisiae
Publication Statistics
PubMed Score 12.17
PubMed score by year
PubTator Score 9.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title