Tbio GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

Protein Summary

Description

Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.

Uniprot Accession IDs

• P15170
• J3KQG6
• Q96GF2
• Eukaryotic peptide chain release factor subunit 3a

Gene Name

• GSPT1

Ensembl ID

• ENST00000420576
• ENSP00000399539
• ENSG00000103342
• ENST00000434724
• ENSP00000398131
• ENST00000439887
• ENSP00000408399
• ENST00000563468
• ENSP00000454351

Symbol

• ERF3A
• GST1
• ETF3A
• eRF3a
• 551G9.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
molecular function	0.97
disease perturbation	0.96
transcription factor binding site profile	0.94
transcription factor perturbation	0.94

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Release Factor / Eukaryotic Peptide Chain Release Factor Gtp-binding Subunit Erf3a

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Peptide Chain Release Factor Gtp-binding Subunit Erf3a

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Eukaryotic Peptide Chain Release Factor Gtp-binding Subunit Erf3a

Protein / Hydrolase / Eukaryotic Peptide Chain Release Factor Gtp-binding Subunit Erf3a

Protein / Enzyme Modulator / G-protein / Eukaryotic Peptide Chain Release Factor Gtp-binding Subunit Erf3a

DTO Classes

Protein / Enzyme / Hydrolase / Eukaryotic Peptide Chain Release Factor Gtp-binding Subunit Erf3a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.19   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 141   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.19   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0