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Tbio
GSKIP
GSK3B-interacting protein

Protein Summary
Description
A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed:27484798, PubMed:25920809, PubMed:16981698). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed:27484798, PubMed:16981698). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed:25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed:19830702). This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000438650
  • ENSP00000412315
  • ENSG00000100744
  • ENST00000554182
  • ENSP00000451384
  • ENST00000555181
  • ENSP00000450420
  • ENST00000556095
  • ENSP00000451188

Symbol
  • C14orf129
  • HSPC210
  • C14orf129
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
tissue sample
0.73
cell type or tissue
0.7
microRNA
0.6
tissue
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.84   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.84   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (6)
GSK3A
Tclin
Family:  Kinase
Novelty:  0.00925708
p_int:  0.999461469
p_ni:  0.000538529
p_wrong:  2e-9
Score:  0.696
Data Source:  BioPlex,STRINGDB
PHF14
Tbio
Family:  Epigenetic
Novelty:  0.13279118
p_int:  0.964671045
p_ni:  0.034322028
p_wrong:  0.001006927
Data Source:  BioPlex
GSK3B
Tclin
Family:  Kinase
Novelty:  0.00095115
Score:  0.791
Data Source:  STRINGDB
ATG2B
Tbio
Novelty:  0.04963717
Score:  0.641
Data Source:  STRINGDB
RBBP6
Tbio
Family:  Enzyme
Novelty:  0.03147368
Score:  0.414
Data Source:  STRINGDB
CDH2
Tbio
Novelty:  0.00040112
Score:  0.41
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
1
3
73.8
maximal oxygen uptake measurement
1
1
1
41.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
73.8
maximal oxygen uptake measurement
1
41.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GSK3B interacting protein
VGNC:3411
453144
Macaque
GSK3B interacting protein
704018
Mouse
MGI:1914037
66787
Rat
RGD:1308470
362778
Dog
GSK3B interacting protein
VGNC:41531
611079
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GSK3B interacting protein
Macaque
GSK3B interacting protein
Mouse
Rat
Dog
GSK3B interacting protein
Publication Statistics
PubMed Score 18.84
PubMed score by year
PubTator Score 4.98
PubTator score by year
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Related Publications
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PMID
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