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Tclin
GSK3B
Glycogen synthase kinase-3 beta

Protein Summary
Description
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquiti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264235
  • ENSP00000264235
  • ENSG00000082701
  • ENST00000316626
  • ENSP00000324806
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
hub protein
1
interacting protein
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 581.5   (req: < 5)
Gene RIFs: 830   (req: <= 3)
Antibodies: 1056   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 581.5   (req: >= 5)
Gene RIFs: 830   (req: > 3)
Antibodies: 1056   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 70
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 704
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (532)
GSK3A
Tclin
Family:  Kinase
Novelty:  0.00925708
p_int:  0.999999851
p_ni:  1.49e-7
Score:  0.907
Data Source:  BioPlex,STRINGDB
TRAK2
Tbio
Novelty:  0.04192075
p_int:  0.999842548
p_ni:  0.000157452
Score:  0.167
Data Source:  BioPlex,STRINGDB
SAMHD1
Tbio
Family:  Enzyme
Novelty:  0.00294595
p_int:  0.999491448
p_ni:  0.000508552
Score:  0.221
Data Source:  BioPlex,STRINGDB
FRAT2
Tbio
Novelty:  0.14416149
p_int:  0.998853736
p_ni:  0.001000683
p_wrong:  0.000145582
Score:  0.977
Data Source:  BioPlex,Reactome,STRINGDB
DEFA5
Tbio
Novelty:  0.00863727
p_int:  0.9851628
p_ni:  0.0148372
Data Source:  BioPlex
AXIN2
Tchem
Novelty:  0.00273189
p_int:  0.969328724
p_ni:  0.030454775
p_wrong:  0.000216501
Score:  0.995
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.966197566
p_ni:  0.033802432
p_wrong:  2e-9
Score:  0.577
Data Source:  BioPlex,STRINGDB
RCAN1
Tbio
Novelty:  0.0030009
p_int:  0.950083491
p_ni:  0.049916509
Score:  0.758
Data Source:  BioPlex,STRINGDB
TRAF2
Tbio
Novelty:  0.00983658
p_int:  0.942000514
p_ni:  0.057999467
p_wrong:  1.9e-8
Score:  0.887
Data Source:  BioPlex,STRINGDB
DKK3
Tbio
Novelty:  0.00519275
p_int:  0.921334072
p_ni:  0.078665924
p_wrong:  5e-9
Score:  0.321
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (219)
AKT phosphorylates targets in the cytosol (R-HSA-198323)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 50
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the cytosol
Reactome
AMER1 mutants destabilize the destruction complex
Reactome
APC truncation mutants have impaired AXIN binding
Reactome
AXIN missense mutants destabilize the destruction complex
Reactome
AXIN mutants destabilize the destruction complex, activating WNT signaling
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the cytosol
AMER1 mutants destabilize the destruction complex
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (83)
Find Similar Targets
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
2
4
74.1
apolipoprotein A 1 measurement
1
1
1
72.9
neutrophil count
2
2
2
65.7
low density lipoprotein cholesterol measurement
2
2
2
64.8
lymphocyte percentage of leukocytes
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
74.1
apolipoprotein A 1 measurement
1
72.9
neutrophil count
2
65.7
low density lipoprotein cholesterol measurement
2
64.8
lymphocyte percentage of leukocytes
1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycogen synthase kinase 3 beta
VGNC:11406
100616510
Macaque
glycogen synthase kinase 3 beta
713114
Mouse
MGI:1861437
56637
Rat
RGD:70982
84027
Dog
glycogen synthase kinase 3 beta
VGNC:41530
478575
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycogen synthase kinase 3 beta
Macaque
glycogen synthase kinase 3 beta
Mouse
Rat
Dog
glycogen synthase kinase 3 beta
Publication Statistics
PubMed Score 581.50
PubMed score by year
PubTator Score 2608.61
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Text