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Tdark
GSE1
Genetic suppressor element 1

Protein Summary
Description
This gene encodes a proline-rich protein with coiled coil domains that may be a subunit of a BRAF35-HDAC (BHC) histone deacetylase complex. This gene may function as an oncogene in breast cancer and enhanced expression of the encoded protein has been observed in breast cancer patients. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253458
  • ENSP00000253458
  • ENSG00000131149
  • ENST00000393243
  • ENSP00000376934
  • ENST00000405402
  • ENSP00000384839

Symbol
  • KIAA0182
  • CRHSP24
  • KIAA0182
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.98
transcription factor
0.95
virus perturbation
0.9
transcription factor perturbation
0.8
PubMedID
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.73   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 45   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.73   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
HMG20A
Tbio
Family:  TF
Novelty:  0.11994252
p_int:  0.999999953
p_ni:  4.6e-8
p_wrong:  1e-9
Score:  0.909
Data Source:  BioPlex,STRINGDB
HMG20B
Tbio
Family:  TF
Novelty:  0.05983143
p_int:  0.999999866
p_ni:  1.33e-7
p_wrong:  1e-9
Score:  0.879
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999999019
p_ni:  9.81e-7
Score:  0.261
Data Source:  BioPlex,STRINGDB
SNAI1
Tbio
Family:  TF
Novelty:  0.00040495
p_int:  0.999986893
p_ni:  0.000013107
Score:  0.816
Data Source:  BioPlex,STRINGDB
CRYAA
Tchem
Novelty:  0.01914081
p_int:  0.999982749
p_ni:  0.00001725
p_wrong:  1e-9
Data Source:  BioPlex
LLGL2
Tbio
Novelty:  0.07084531
p_int:  0.999973276
p_ni:  0.000026724
p_wrong:  1e-9
Score:  0.351
Data Source:  BioPlex,STRINGDB
DOK4
Tbio
Novelty:  0.06349482
p_int:  0.999952904
p_ni:  0.000047096
Score:  0.499
Data Source:  BioPlex,STRINGDB
FGF1
Tchem
Novelty:  0.00055979
p_int:  0.999946208
p_ni:  0.000053791
Score:  0.795
Data Source:  BioPlex,STRINGDB
TCF4
Tbio
Family:  TF
Novelty:  0.0019718
p_int:  0.999683854
p_ni:  0.000316146
Score:  0.313
Data Source:  BioPlex,STRINGDB
HAO2
Tchem
Family:  Enzyme
Novelty:  0.03029536
p_int:  0.946808579
p_ni:  0.053191414
p_wrong:  7e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
7
8
97.3
mean platelet volume
2
3
4
89.3
eosinophil percentage of leukocytes
1
4
4
89.2
platelet crit
2
2
3
89
balding measurement
1
2
2
80.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
8
97.3
mean platelet volume
4
89.3
eosinophil percentage of leukocytes
4
89.2
platelet crit
3
89
balding measurement
2
80.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Gse1 coiled-coil protein
VGNC:9045
454292
Macaque
Gse1 coiled-coil protein
693298
Mouse
MGI:1098275
382034
Rat
RGD:1562686
307913
Dog
Gse1 coiled-coil protein
VGNC:41527
609446
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Gse1 coiled-coil protein
Macaque
Gse1 coiled-coil protein
Mouse
Rat
Dog
Gse1 coiled-coil protein
Publication Statistics
PubMed Score 22.73
PubMed score by year
PubTator Score 9.55
PubTator score by year
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Related Publications
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PMID
Year
Title