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Tbio
GRXCR2
Glutaredoxin domain-containing cysteine-rich protein 2

Protein Summary
Description
Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection. This gene encodes a protein containing a glutaredoxin domain, which functions in protein S-glutathionylation. A mutation in this gene was found in a family with autoosomal recessive nonsyndromic sensorineural deafness-101. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377976
  • ENSP00000367214
  • ENSG00000204928

Symbol
  • DFNB101
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.71
tissue
0.52
cell line
0.51
protein complex
0.41
biological term
0.33


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.92   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 16   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.92   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 16   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
PLAC8L1
Tdark
Novelty:  2.10744169
Score:  0.828
Data Source:  STRINGDB
YIPF5
Tbio
Novelty:  0.08206828
Score:  0.761
Data Source:  STRINGDB
RBM27
Tdark
Novelty:  0.04875536
Score:  0.714
Data Source:  STRINGDB
BLOC1S2
Tbio
Novelty:  0.02346362
Score:  0.652
Data Source:  STRINGDB
LOXHD1
Tbio
Family:  Enzyme
Novelty:  0.06557997
Score:  0.604
Data Source:  STRINGDB
GIPC3
Tbio
Novelty:  0.14970604
Score:  0.6
Data Source:  STRINGDB
CAP2
Tbio
Family:  Enzyme
Novelty:  0.1142507
Score:  0.559
Data Source:  STRINGDB
CAP1
Tbio
Family:  Enzyme
Novelty:  0.0333464
Score:  0.559
Data Source:  STRINGDB
STRC
Tbio
Novelty:  0.01587212
Score:  0.556
Data Source:  STRINGDB
PRELID2
Tdark
Novelty:  0.38276284
Score:  0.552
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
MGI
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
17.8
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutaredoxin and cysteine rich domain containing 2
VGNC:4022
740444
Macaque
glutaredoxin and cysteine rich domain containing 2
706463
Mouse
MGI:2685697
332309
Rat
RGD:1584696
681048
Dog
glutaredoxin and cysteine rich domain containing 2
VGNC:41523
100686755
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutaredoxin and cysteine rich domain containing 2
Macaque
glutaredoxin and cysteine rich domain containing 2
Mouse
Rat
Dog
glutaredoxin and cysteine rich domain containing 2
Publication Statistics
PubMed Score 3.92
PubMed score by year
PubTator Score 0.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title