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Tdark
GRXCR1
Glutaredoxin domain-containing cysteine-rich protein 1

Protein Summary
Description
May play a role in actin filament architecture in developing stereocilia of sensory cells. This gene is one of 60 loci associated with autosomal-recessive nonsyndromic hearing impairment. This gene encodes a protein which contains GRX-like domains; these domains play a role in the S-glutathionylation of proteins and may be involved in actin organization in hair cells. [provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399770
  • ENSP00000382670
  • ENSG00000215203

Symbol
  • DFNB25
  • DFNB25
  • PPP1R88
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.71
cell type or tissue
0.63
biological process
0.52
trait
0.46
cell line
0.45


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.14   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.14   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
CAP2
Tbio
Family:  Enzyme
Novelty:  0.1142507
Score:  0.943
Data Source:  STRINGDB
ATP8A1
Tbio
Family:  Transporter
Novelty:  0.02003643
Score:  0.905
Data Source:  STRINGDB
SERINC3
Tbio
Novelty:  0.02507683
Score:  0.905
Data Source:  STRINGDB
GLRX
Tbio
Novelty:  0.00111903
Score:  0.763
Data Source:  STRINGDB
ACADM
Tbio
Family:  Enzyme
Novelty:  0.00548721
Score:  0.755
Data Source:  STRINGDB
CAP1
Tbio
Family:  Enzyme
Novelty:  0.0333464
Score:  0.732
Data Source:  STRINGDB
GIPC3
Tbio
Novelty:  0.14970604
Score:  0.682
Data Source:  STRINGDB
ANKRD24
Tdark
Novelty:  1.1511349
Score:  0.676
Data Source:  STRINGDB
PJVK
Tbio
Novelty:  0.0419213
Score:  0.652
Data Source:  STRINGDB
TMPRSS3
Tbio
Family:  Enzyme
Novelty:  0.0268524
Score:  0.63
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutaredoxin and cysteine rich domain containing 1
VGNC:8264
461192
Macaque
glutaredoxin and cysteine rich domain containing 1
702860
Mouse
MGI:3577767
433899
Rat
RGD:1564635
498355
Dog
glutaredoxin and cysteine rich domain containing 1
VGNC:41522
100687779
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutaredoxin and cysteine rich domain containing 1
Macaque
glutaredoxin and cysteine rich domain containing 1
Mouse
Rat
Dog
glutaredoxin and cysteine rich domain containing 1
Publication Statistics
PubMed Score 6.14
PubMed score by year
PubTator Score 5.67
PubTator score by year
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Related Publications
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PMID
Year
Title