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Tdark
GRTP1
Growth hormone-regulated TBC protein 1

Protein Summary
Description
May act as a GTPase-activating protein for Rab family protein(s).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326039
  • ENSP00000321850
  • ENSG00000139835
  • ENST00000375430
  • ENSP00000364579
  • ENST00000375431
  • ENSP00000364580

Symbol
  • TBC1D6
  • TBC1D6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.7
interacting protein
0.7
histone modification site profile
0.69
transcription factor perturbation
0.68
PubMedID
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.12   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.12   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
PCDHGC3
Tbio
Novelty:  0.07203024
p_int:  0.999942653
p_ni:  0.000057346
Score:  0.177
Data Source:  BioPlex,STRINGDB
GJB7
Tbio
Novelty:  0.12555147
p_int:  0.999814898
p_ni:  0.000184991
p_wrong:  1.1e-7
Data Source:  BioPlex
TBRG1
Tbio
Novelty:  0.02003439
p_int:  0.999501766
p_ni:  0.00034095
p_wrong:  0.000157284
Data Source:  BioPlex
MINDY1
Tbio
Novelty:  0.31540765
p_int:  0.993127838
p_ni:  0.006245827
p_wrong:  0.000626335
Score:  0.227
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.956561149
p_ni:  0.043438851
Score:  0.159
Data Source:  BioPlex,STRINGDB
ATP2A1
Tchem
Family:  Transporter
Novelty:  0.00355092
p_int:  0.946433226
p_ni:  0.053566774
Score:  0.232
Data Source:  BioPlex,STRINGDB
PLBD1
Tdark
Family:  Enzyme
Novelty:  0.27639575
Score:  0.674
Data Source:  STRINGDB
TBC1D22A
Tbio
Novelty:  0.46374046
Score:  0.665
Data Source:  STRINGDB
RHBDD2
Tbio
Family:  Enzyme
Novelty:  0.17415558
Score:  0.644
Data Source:  STRINGDB
TBC1D20
Tbio
Novelty:  0.08651866
Score:  0.622
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
8
9
99
platelet count
4
4
5
87.9
C-reactive protein measurement
4
2
4
73.8
1
1
0
6.3
61.3
mean reticulocyte volume
1
1
1
59.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
9
99
platelet count
5
87.9
C-reactive protein measurement
4
73.8
0
6.3
61.3
mean reticulocyte volume
1
59.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth hormone regulated TBC protein 1
VGNC:13113
745038
Macaque
growth hormone-regulated TBC protein 1-like
106994403
Mouse
MGI:1914040
66790
Dog
growth hormone regulated TBC protein 1
VGNC:41520
476996
Cow
growth hormone regulated TBC protein 1
VGNC:29668
100125303
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth hormone regulated TBC protein 1
Macaque
growth hormone-regulated TBC protein 1-like
Mouse
Dog
growth hormone regulated TBC protein 1
Cow
growth hormone regulated TBC protein 1
Publication Statistics
PubMed Score 1.12
PubMed score by year
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Related Publications
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PMID
Year
Title