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Tbio
GRPEL1
GrpE protein homolog 1, mitochondrial

Protein Summary
Description
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner (By similarity). Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (PubMed:11311562).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264954
  • ENSP00000264954
  • ENSG00000109519

Symbol
  • GREPEL1
  • GrpE
  • HMGE
  • mt-GrpE#1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
disease perturbation
0.87
histone modification site profile
0.87
interacting protein
0.84
transcription factor binding site profile
0.77


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 528.49   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 528.49   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (218)
PALLD
Tbio
Novelty:  0.01191944
p_int:  0.999998797
p_ni:  0.000001202
p_wrong:  1e-9
Score:  0.513
Data Source:  BioPlex,STRINGDB
HSPA9
Tchem
Novelty:  0.00235171
p_int:  0.99998938
p_ni:  0.00001062
Score:  0.999
Data Source:  BioPlex,STRINGDB
GRPEL2
Tdark
Novelty:  0.52660174
p_int:  0.999696714
p_ni:  0.000303286
Score:  0.928
Data Source:  BioPlex,STRINGDB
DENND2D
Tbio
Novelty:  0.16496649
p_int:  0.998536662
p_ni:  0.001463338
Score:  0.524
Data Source:  BioPlex,STRINGDB
SPATA24
Tdark
Novelty:  0.95478351
p_int:  0.989800321
p_ni:  0.010199679
Score:  0.19
Data Source:  BioPlex,STRINGDB
PROSER2
Tdark
Novelty:  0.56334611
p_int:  0.931205542
p_ni:  0.068794458
Score:  0.186
Data Source:  BioPlex,STRINGDB
TPPP
Tbio
Novelty:  0.00716994
p_int:  0.926881925
p_ni:  0.070823933
p_wrong:  0.002294142
Score:  0.332
Data Source:  BioPlex,STRINGDB
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.755439643
p_ni:  0.244560357
Data Source:  BioPlex
C6orf222
Tdark
Novelty:  37
p_int:  0.754038319
p_ni:  0.245961681
Data Source:  BioPlex
TIMM44
Tbio
Family:  Enzyme
Novelty:  0.020862
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
4
4
5
97.8
monocyte percentage of leukocytes
2
3
3
90.2
neutrophil count
2
2
3
89.2
lymphocyte percentage of leukocytes
2
2
2
83
platelet crit
2
1
2
82.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
5
97.8
monocyte percentage of leukocytes
3
90.2
neutrophil count
3
89.2
lymphocyte percentage of leukocytes
2
83
platelet crit
2
82.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GrpE like 1, mitochondrial
471135
Mouse
MGI:1334417
17713
Rat
RGD:70947
79563
Dog
GrpE like 1, mitochondrial
VGNC:41517
488784
Horse
GrpE like 1, mitochondrial
VGNC:18609
100056606
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GrpE like 1, mitochondrial
Mouse
Rat
Dog
GrpE like 1, mitochondrial
Horse
GrpE like 1, mitochondrial
Publication Statistics
PubMed Score 528.49
PubMed score by year
PubTator Score 50.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title