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Tbio
GRP
Gastrin-releasing peptide

Protein Summary
Description
Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity). This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. The encoded preproprotein is proteolytically processed to generate two peptides, gastrin-releasing peptide and neuromedin-C. These peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in mul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256857
  • ENSP00000256857
  • ENSG00000134443
  • ENST00000420468
  • ENSP00000389696
  • ENST00000529320
  • ENSP00000434101

Symbol
  • BN
  • GRP-10
  • proGRP
  • preproGRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.82
PubMedID
0.8
disease perturbation
0.62
biological term
0.59
cell type or tissue
0.5


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3162.79   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3162.79   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (262)
SUFU
Tbio
Novelty:  0.00475249
p_int:  0.999997631
p_ni:  0.000002369
Data Source:  BioPlex
DALRD3
Tdark
Novelty:  0.5378666
p_int:  0.998826424
p_ni:  0.000001164
p_wrong:  0.001172412
Data Source:  BioPlex
CDKN2C
Tbio
Family:  Enzyme
Novelty:  0.00806886
p_int:  0.998634875
p_ni:  0.001152678
p_wrong:  0.000212448
Data Source:  BioPlex
CETN3
Tbio
Novelty:  0.00705513
p_int:  0.994634802
p_ni:  0.005364653
p_wrong:  5.45e-7
Data Source:  BioPlex
CCDC51
Tdark
Novelty:  1.19203634
p_int:  0.926583351
p_ni:  0.072413701
p_wrong:  0.001002948
Data Source:  BioPlex
ADO
Tbio
Family:  Enzyme
Novelty:  0.04529593
p_int:  0.891545486
p_ni:  0.000665876
p_wrong:  0.107788638
Data Source:  BioPlex
THNSL1
Tdark
Family:  Enzyme
Novelty:  1.98275016
p_int:  0.852143651
p_ni:  0.147856229
p_wrong:  1.2e-7
Data Source:  BioPlex
DCTN3
Tbio
Novelty:  0.14551388
p_int:  0.845691428
p_ni:  0.154290353
p_wrong:  0.000018219
Data Source:  BioPlex
GNB1L
Tbio
Novelty:  0.03388865
p_int:  0.75864951
p_ni:  0.241350475
p_wrong:  1.6e-8
Data Source:  BioPlex
UGDH
Tbio
Family:  Enzyme
Novelty:  0.00284931
p_int:  0.758101302
p_ni:  0.241898698
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Incretin synthesis, secretion, and inactivation
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Incretin synthesis, secretion, and inactivation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
2
2
1.1
91.5
3
3
2
1.1
56.2
body mass index
5
1
6
30.1
insomnia measurement
1
1
0
1
14.2
appendicular lean mass
1
1
1
8.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1.1
91.5
2
1.1
56.2
body mass index
6
30.1
insomnia measurement
0
1
14.2
appendicular lean mass
1
8.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gastrin releasing peptide
VGNC:7316
736808
Macaque
gastrin releasing peptide
696983
Mouse
MGI:95833
225642
Rat
RGD:621740
171101
Dog
gastrin releasing peptide
VGNC:53721
610154
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gastrin releasing peptide
Macaque
gastrin releasing peptide
Mouse
Rat
Dog
gastrin releasing peptide
Publication Statistics
PubMed Score 3162.79
PubMed score by year
PubTator Score 1618.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title