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Tchem
GRM8
Metabotropic glutamate receptor 8

Protein Summary
Description
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339582
  • ENSP00000344173
  • ENSG00000179603
  • ENST00000341617
  • ENSP00000345747
  • ENST00000358373
  • ENSP00000351142
  • ENST00000472701
  • ENSP00000419832

Symbol
  • GPRC1H
  • MGLUR8
  • GLUR8
  • mGlu8
  • GPRC1H
  • MGLUR8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
trait
0.97
histone modification site profile
0.8
transcription factor
0.78
gene perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.93   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 352   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.93   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 352   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (290)
SSTR5
Tclin
Family:  GPCR
Novelty:  0.00568309
Score:  0.957
Data Source:  STRINGDB
NPY
Tbio
Novelty:  0.00012637
Score:  0.956
Data Source:  STRINGDB
CHRM2
Tclin
Family:  GPCR
Novelty:  0.00326718
Score:  0.954
Data Source:  STRINGDB
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
Score:  0.953
Data Source:  STRINGDB
DRD2
Tclin
Family:  GPCR
Novelty:  0.00033797
Score:  0.94
Data Source:  STRINGDB
HTR1A
Tclin
Family:  GPCR
Novelty:  0.00015658
Score:  0.938
Data Source:  STRINGDB
HRH3
Tclin
Family:  GPCR
Novelty:  0.00148904
Score:  0.936
Data Source:  STRINGDB
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
Score:  0.934
Data Source:  STRINGDB
CNR1
Tclin
Family:  GPCR
Novelty:  0.00060063
Score:  0.933
Data Source:  STRINGDB
DRD4
Tchem
Family:  GPCR
Novelty:  0.00099622
Score:  0.933
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (25)
Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
5
11
4
5.9
88.3
feeling emotionally hurt measurement
1
4
0
7.1
83.2
1
1
0
1.2
80.2
mathematical ability
3
2
4
76.7
anxiety measurement
1
1
1
72.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
4
5.9
88.3
feeling emotionally hurt measurement
0
7.1
83.2
0
1.2
80.2
mathematical ability
4
76.7
anxiety measurement
1
72.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
glutamate metabotropic receptor 8
697465
Mouse
MGI:1351345
14823
Rat
RGD:619858
60590
Dog
glutamate metabotropic receptor 8
VGNC:41515
482270
Horse
glutamate metabotropic receptor 8
VGNC:18606
100071655
Species
Name
OMA
EggNOG
Inparanoid
Macaque
glutamate metabotropic receptor 8
Mouse
Rat
Dog
glutamate metabotropic receptor 8
Horse
glutamate metabotropic receptor 8
Publication Statistics
PubMed Score 114.93
PubMed score by year
PubTator Score 24.14
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title