Tchem GRM5 Metabotropic glutamate receptor 5

Protein Summary

Description

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Uniprot Accession IDs

• P41594
• Q6J164
• mGluR5

Gene Name

• GRM5

Ensembl ID

• ENST00000305432
• ENSP00000305905
• ENSG00000168959
• ENST00000305447
• ENSP00000306138
• ENST00000455756
• ENSP00000405690

Symbol

• GPRC1E
• MGLUR5
• mGlu5
• GPRC1E
• MGLUR5
• PPP1R86

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	1
protein domain	0.99
hub protein	0.92
biological process	0.88
trait	0.86

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Metabotropic Glutamate Receptor 5

DTO Classes

Protein / G-protein Coupled Receptor / Class C Metabotropic Glutamate/pheromone / Metabotropic Glutamate Receptor / Metabotropic Glutamate Receptor 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1818.09   (req: < 5)

Gene RIFs: 95   (req: <= 3)

Antibodies: 498   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1818.09   (req: >= 5)

Gene RIFs: 95   (req: > 3)

Antibodies: 498   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1174

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2