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Tchem
GRM4
Metabotropic glutamate receptor 4

Protein Summary
Description
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374177
  • ENSP00000363292
  • ENSG00000124493
  • ENST00000455714
  • ENSP00000398456
  • ENST00000535756
  • ENSP00000437925
  • ENST00000538487
  • ENSP00000440556
  • ENST00000544773
  • ENSP00000437730
  • ENST00000609222
  • ENSP00000477466

Symbol
  • GPRC1D
  • MGLUR4
  • mGlu4
  • GPRC1D
  • MGLUR4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
ligand (chemical)
0.9
co-expressed gene
0.87
biological process
0.73
cellular component
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 302.69   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 302.69   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 138
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1