Tchem GRM2 Metabotropic glutamate receptor 2

Protein Summary

Description

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]

Uniprot Accession IDs

• Q14416
• B0M0K7
• Q14CU5
• Q52MC6
• Q9H3N6
• mGluR2

Gene Name

• GRM2

Ensembl ID

• ENST00000395052
• ENSP00000378492
• ENSG00000164082

Symbol

• GPRC1B
• MGLUR2
• GLUR2
• mGlu2
• GPRC1B
• MGLUR2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	0.99
protein domain	0.97
gene perturbation	0.78
virus perturbation	0.72
biological process	0.66

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Metabotropic Glutamate Receptor 2

DTO Classes

Protein / G-protein Coupled Receptor / Class C Metabotropic Glutamate/pheromone / Metabotropic Glutamate Receptor / Metabotropic Glutamate Receptor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 920.85   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 477   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 920.85   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 477   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 813

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1