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Tchem
GRM2
Metabotropic glutamate receptor 2

Protein Summary
Description
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phos ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395052
  • ENSP00000378492
  • ENSG00000164082

Symbol
  • GPRC1B
  • MGLUR2
  • GLUR2
  • mGlu2
  • GPRC1B
  • MGLUR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.99
protein domain
0.97
gene perturbation
0.78
virus perturbation
0.72
biological process
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 851.97   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 477   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 851.97   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 477   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 790
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (302)
DRD2
Tclin
Family:  GPCR
Novelty:  0.00033797
Score:  0.965
Data Source:  STRINGDB
HTR1A
Tclin
Family:  GPCR
Novelty:  0.00015658
Score:  0.96
Data Source:  STRINGDB
CNR1
Tclin
Family:  GPCR
Novelty:  0.00060063
Score:  0.955
Data Source:  STRINGDB
DRD3
Tclin
Family:  GPCR
Novelty:  0.00230028
Score:  0.953
Data Source:  STRINGDB
DRD4
Tchem
Family:  GPCR
Novelty:  0.00099622
Score:  0.952
Data Source:  STRINGDB
OPRM1
Tclin
Family:  GPCR
Novelty:  0.0003701
Score:  0.946
Data Source:  STRINGDB
OPRL1
Tchem
Family:  GPCR
Novelty:  0.00186729
Score:  0.945
Data Source:  STRINGDB
OPRK1
Tclin
Family:  GPCR
Novelty:  0.00171044
Score:  0.944
Data Source:  STRINGDB
OPRD1
Tclin
Family:  GPCR
Novelty:  0.00757692
Score:  0.943
Data Source:  STRINGDB
GABBR1
Tclin
Family:  GPCR
Novelty:  0.00086493
Score:  0.938
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (26)
Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
42.3
macrophage inflammatory protein 1b measurement
1
1
1
38.8
body height
1
1
1
7.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
42.3
macrophage inflammatory protein 1b measurement
1
38.8
body height
1
7.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate metabotropic receptor 2
VGNC:11405
100611779
Macaque
glutamate metabotropic receptor 2
700214
Mouse
MGI:1351339
108068
Rat
RGD:2743
24415
Dog
glutamate metabotropic receptor 2
VGNC:41509
484751
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate metabotropic receptor 2
Macaque
glutamate metabotropic receptor 2
Mouse
Rat
Dog
glutamate metabotropic receptor 2
Publication Statistics
PubMed Score 851.97
PubMed score by year
PubTator Score 62.88
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title