Protein Summary
Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO). This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008]
- ENST00000264952
- ENSP00000264952
- ENSG00000114124
- GPRK7
- GPRK7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
molecular function | 0.93 | ||
tissue sample | 0.69 | ||
cell line | 0.49 | ||
metabolite | 0.45 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 52.06 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 204 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 52.06 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 204 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (3)
Protein-Protein Interactions (75)
Nearest Tclin Targets (3)
Downstream (3)
1 – 3 of 3
Pathways (18)
Reactome (7)
KEGG (3)
PathwayCommons (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | Inactivation, recovery and regulation of the phototransduction cascade | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
Inactivation, recovery and regulation of the phototransduction cascade | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (3)
Components (1)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 3 | 2 | 3 | 86.1 | |||||
hair color | 1 | 1 | 0 | 1.1 | 71.3 | ||||
1 | 1 | 1 | 15.8 | ||||||
susceptibility to Mycobacterium tuberculosis infection measurement | 1 | 1 | 1 | 15.8 | |||||
leukocyte count | 1 | 1 | 1 | 8.3 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 3 | 86.1 | |||||
hair color | 0 | 1.1 | 71.3 | ||||
1 | 15.8 | ||||||
susceptibility to Mycobacterium tuberculosis infection measurement | 1 | 15.8 | |||||
leukocyte count | 1 | 8.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | G protein-coupled receptor kinase 7 | 714916 | ||||||
Dog | G protein-coupled receptor kinase 7 | VGNC:41507 | 485693 | |||||
Horse | G protein-coupled receptor kinase 7 | VGNC:18598 | 100062922 | |||||
Cow | G protein-coupled receptor kinase 7 | VGNC:29658 | 281802 | |||||
Pig | G protein-coupled receptor kinase 7 | 397114 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | G protein-coupled receptor kinase 7 | |||||
Dog | G protein-coupled receptor kinase 7 | |||||
Horse | G protein-coupled receptor kinase 7 | |||||
Cow | G protein-coupled receptor kinase 7 | |||||
Pig | G protein-coupled receptor kinase 7 | |||||
Publication Statistics
PubMed Score 52.06
PubMed score by year
PubTator Score 62.46
PubTator score by year
Patents
Patents by year
Related Publications
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Text |
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