Protein Summary
Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]
- ENST00000335678
- ENSP00000334876
- ENSG00000185974
- RHOK
- RK
- RHOK
- GPRK1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
molecular function | 0.93 | ||
biological process | 0.71 | ||
cellular component | 0.61 | ||
hub protein | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 137.75 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 234 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 137.75 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 234 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (3)
Protein-Protein Interactions (105)
Nearest Tclin Targets (3)
Downstream (3)
1 – 3 of 3
Pathways (14)
Reactome (7)
KEGG (3)
PathwayCommons (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | G alpha (i) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | Inactivation, recovery and regulation of the phototransduction cascade | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
G alpha (i) signalling events | ||||
GPCR downstream signalling | ||||
Inactivation, recovery and regulation of the phototransduction cascade | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (4)
Components (1)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
total cholesterol measurement | 1 | 1 | 1 | 51.4 | |||||
mean corpuscular volume | 1 | 1 | 1 | 38.2 | |||||
triglyceride measurement | 1 | 1 | 1 | 28.1 | |||||
sleep measurement | 1 | 1 | 1 | 26.6 | |||||
body height | 1 | 1 | 1 | 10.6 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
total cholesterol measurement | 1 | 51.4 | |||||
mean corpuscular volume | 1 | 38.2 | |||||
triglyceride measurement | 1 | 28.1 | |||||
sleep measurement | 1 | 26.6 | |||||
body height | 1 | 10.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | G protein-coupled receptor kinase 1 | VGNC:13112 | 467338 | |||||
Macaque | G protein-coupled receptor kinase 1 | 715484 | ||||||
Mouse | MGI:1345146 | 24013 | ||||||
Rat | RGD:619712 | 81760 | ||||||
Dog | G protein-coupled receptor kinase 1 | VGNC:41501 | 485557 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | G protein-coupled receptor kinase 1 | |||||
Macaque | G protein-coupled receptor kinase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | G protein-coupled receptor kinase 1 | |||||
Publication Statistics
PubMed Score 137.75
PubMed score by year
PubTator Score 104.40
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (39)
GeneRif Annotations (18)
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0 of 0
PMID | Year | Title |
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