You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GRIPAP1
GRIP1-associated protein 1

Protein Summary
Description
Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). GRASP-1 C-terminal chain: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function. [provided by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376423
  • ENSP00000365606
  • ENSG00000068400
  • ENST00000593475
  • ENSP00000469842

Symbol
  • KIAA1167
  • GRASP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
cell type or tissue
0.8
kinase perturbation
0.76
interacting protein
0.72
tissue
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.99   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.99   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
TCP10L
Tbio
Novelty:  0.24089479
p_int:  0.999999994
p_ni:  6e-9
Score:  0.258
Data Source:  BioPlex,STRINGDB
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.999999961
p_ni:  4e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
NDEL1
Tbio
Novelty:  0.01241819
p_int:  0.999999834
p_ni:  1.66e-7
Score:  0.391
Data Source:  BioPlex,STRINGDB
CCDC183
Tdark
Novelty:  1.55719016
p_int:  0.999999291
p_ni:  7.09e-7
Score:  0.513
Data Source:  BioPlex,STRINGDB
TCP10L2
Tdark
Novelty:  4.42416561
p_int:  0.999998786
p_ni:  0.000001214
Score:  0.826
Data Source:  BioPlex,STRINGDB
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.999996742
p_ni:  0.000003258
Data Source:  BioPlex
CYB5D2
Tbio
Novelty:  0.23122479
p_int:  0.998756814
p_ni:  0.001243186
Score:  0.19
Data Source:  BioPlex,STRINGDB
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.995693208
p_ni:  0.004306792
Data Source:  BioPlex
CGNL1
Tbio
Novelty:  0.03970695
p_int:  0.803705456
p_ni:  0.196294543
p_wrong:  1e-9
Score:  0.332
Data Source:  BioPlex,STRINGDB
GRIP2
Tdark
Novelty:  0.0661318
Score:  0.845
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
59.8
eosinophil percentage of leukocytes
1
1
1
56.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
59.8
eosinophil percentage of leukocytes
1
56.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
GRIP1 associated protein 1
715113
Mouse
MGI:1859616
54645
Rat
RGD:621249
116493
Dog
GRIP1 associated protein 1
VGNC:41500
491871
Cow
GRIP1 associated protein 1
VGNC:29653
515550
Species
Name
OMA
EggNOG
Inparanoid
Macaque
GRIP1 associated protein 1
Mouse
Rat
Dog
GRIP1 associated protein 1
Cow
GRIP1 associated protein 1
Publication Statistics
PubMed Score 10.99
PubMed score by year
PubTator Score 8.15
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title