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Tdark
GRIP2
Glutamate receptor-interacting protein 2

Protein Summary
Description
May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000621039
  • ENSP00000478352
  • ENSG00000144596

Symbol
  • KIAA1719
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
cell type or tissue
0.84
tissue sample
0.64
small molecule perturbation
0.61
microRNA
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.34   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.34   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
GRIA2
Tclin
Family:  IC
Novelty:  0.00141257
Score:  0.975
Data Source:  Reactome,STRINGDB
PICK1
Tbio
Novelty:  0.0058265
Score:  0.974
Data Source:  Reactome,STRINGDB
GRIA3
Tclin
Family:  IC
Novelty:  0.00584546
Score:  0.962
Data Source:  Reactome,STRINGDB
GRIA1
Tclin
Family:  IC
Novelty:  0.0005008
Score:  0.95
Data Source:  Reactome,STRINGDB
GRIA4
Tclin
Family:  IC
Novelty:  0.00284417
Score:  0.945
Data Source:  Reactome,STRINGDB
GRIP1
Tbio
Novelty:  0.00343871
Score:  0.925
Data Source:  STRINGDB
PRKCG
Tchem
Family:  Kinase
Novelty:  0.00291817
Score:  0.912
Data Source:  STRINGDB
NSF
Tbio
Family:  Enzyme
Novelty:  0.00173489
Score:  0.912
Data Source:  STRINGDB
PRKCA
Tchem
Family:  Kinase
Novelty:  0.00057611
Score:  0.909
Data Source:  STRINGDB
PRKCB
Tchem
Family:  Kinase
Novelty:  0.00189802
Score:  0.909
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Glutamate binding, activation of AMPA receptors and synaptic plasticity (R-HSA-399721)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Trafficking of AMPA receptors
Reactome
Trafficking of GluR2-containing AMPA receptors
Name
Explore in Pharos
Explore in Source
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
42.3
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
glutamate receptor interacting protein 2
702096
Mouse
MGI:2681173
243547
Rat
RGD:621668
171571
Dog
glutamate receptor interacting protein 2
VGNC:41499
484638
Xenopus
glutamate receptor interacting protein 2
XB-GENE-854056
100495373
Species
Name
OMA
EggNOG
Inparanoid
Macaque
glutamate receptor interacting protein 2
Mouse
Rat
Dog
glutamate receptor interacting protein 2
Xenopus
glutamate receptor interacting protein 2
Publication Statistics
PubMed Score 13.34
PubMed score by year
PubTator Score 11.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title