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Tclin
GRIN1
Glutamate receptor ionotropic, NMDA 1

Protein Summary
Description
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:26919761). The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371546
  • ENSP00000360601
  • ENSG00000176884
  • ENST00000371550
  • ENSP00000360605
  • ENST00000371553
  • ENSP00000360608
  • ENST00000371559
  • ENSP00000360614
  • ENST00000371560
  • ENSP00000360615
  • ENST00000371561
  • ENSP00000360616

Symbol
  • NMDAR1
  • NR1
  • MRD8
  • GluN1
  • NMDA1
  • NDHMSD
  • NDHMSR
  • NMD-R1
  • NMDAR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
biological term
0.88
chemical
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 910.93   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 1174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 910.93   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 1174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 75
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (362)
DLG4
Tchem
Novelty:  0.00057285
Score:  0.993
Data Source:  Reactome,STRINGDB
GRIN2B
Tclin
Family:  IC
Novelty:  0.00035058
Score:  0.991
Data Source:  Reactome,STRINGDB
GRIN2A
Tclin
Family:  IC
Novelty:  0.00060035
Score:  0.99
Data Source:  Reactome,STRINGDB
CAMK2G
Tchem
Family:  Kinase
Novelty:  0.04642387
Score:  0.98
Data Source:  Reactome,STRINGDB
CAMK2A
Tchem
Family:  Kinase
Novelty:  0.00534906
Score:  0.979
Data Source:  Reactome,STRINGDB
DLG3
Tbio
Novelty:  0.01196565
Score:  0.977
Data Source:  Reactome,STRINGDB
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
Score:  0.977
Data Source:  Reactome,STRINGDB
GRIN2D
Tclin
Family:  IC
Novelty:  0.00457474
Score:  0.975
Data Source:  Reactome,STRINGDB
DLG2
Tbio
Novelty:  0.00999909
Score:  0.975
Data Source:  Reactome,STRINGDB
GRIN2C
Tclin
Family:  IC
Novelty:  0.00430771
Score:  0.972
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (62)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 27
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
Axon guidance
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
Axon guidance
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Cytokine Signaling in Immune system
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (75)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
3
4
89.1
monocyte percentage of leukocytes
2
2
2
88
creatinine measurement
1
2
2
86.1
reticulocyte measurement
3
1
3
82.3
reticulocyte count
6
1
6
80.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
4
89.1
monocyte percentage of leukocytes
2
88
creatinine measurement
2
86.1
reticulocyte measurement
3
82.3
reticulocyte count
6
80.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor NMDA type subunit 1
VGNC:53282
465176
Macaque
glutamate ionotropic receptor NMDA type subunit 1
574380
Mouse
MGI:95819
14810
Rat
RGD:2736
24408
Dog
glutamate ionotropic receptor NMDA type subunit 1
VGNC:41491
494007
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor NMDA type subunit 1
Macaque
glutamate ionotropic receptor NMDA type subunit 1
Mouse
Rat
Dog
glutamate ionotropic receptor NMDA type subunit 1
Publication Statistics
PubMed Score 910.93
PubMed score by year
PubTator Score 824.20
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title