Tclin GRIN1 Glutamate receptor ionotropic, NMDA 1

Protein Summary

Description

Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:26919761). The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q05586
• A6NLK7
• A6NLR1
• C9K0X1
• P35437
• Q12867
• Q12868
• Q5VSF3
• Q5VSF4
• Q5VSF5
• Q5VSF6
• Q5VSF7
• Q5VSF8
• Q9UPF8
• Q9UPF9
• GluN1

Gene Name

• GRIN1

Ensembl ID

• ENST00000371546
• ENSP00000360601
• ENSG00000176884
• ENST00000371550
• ENSP00000360605
• ENST00000371553
• ENSP00000360608
• ENST00000371559
• ENSP00000360614
• ENST00000371560
• ENSP00000360615
• ENST00000371561
• ENSP00000360616

Symbol

• NMDAR1
• NR1
• MRD8
• GluN1
• NMDA1
• NDHMSD
• NDHMSR
• NMD-R1
• NMDAR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
hub protein	1
molecular function	1
biological term	0.88
chemical	0.87

Protein Classes

DTO Classes

Protein / Ion Channel / Glutamate-gated Ion Channel (Gic) Family Of Neurotransmitter Receptors / Nr1/grin1 Subfamily / Glutamate Receptor Ionotropic, Nmda 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 971.11   (req: < 5)

Gene RIFs: 132   (req: <= 3)

Antibodies: 1174   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 971.11   (req: >= 5)

Gene RIFs: 132   (req: > 3)

Antibodies: 1174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 75

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4