Tclin GRIK3 Glutamate receptor ionotropic, kainate 3

Protein Summary

Description

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q13003
• A9Z1Z8
• B1AMS6
• Q13004
• Q16136
• GluK3

Gene Name

• GRIK3

Ensembl ID

• ENST00000373091
• ENSP00000362183
• ENSG00000163873
• ENST00000373093
• ENSP00000362185

Symbol

• GLUR7
• EAA5
• GLR7
• GLUR7
• GluK3
• GluR7a

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.86
protein domain	0.73
microRNA	0.72
PubMedID	0.64
cell type or tissue	0.62

Protein Classes

DTO Classes

Protein / Ion Channel / Glutamate-gated Ion Channel (Gic) Family Of Neurotransmitter Receptors / Grik3 Subfamily / Glutamate Receptor Ionotropic, Kainate 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.35   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 172   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.35   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3