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Tclin
GRIK1
Glutamate receptor ionotropic, kainate 1

Protein Summary
Description
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is t ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389125
  • ENSP00000373777
  • ENSG00000171189
  • ENST00000399907
  • ENSP00000382791

Symbol
  • GLUR5
  • EAA3
  • EEA3
  • GLR5
  • GLUR5
  • GluK1
  • gluR-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.94
trait
0.93
molecular function
0.81
cellular component
0.76
disease
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.4   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 275   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.4   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 160
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (160)
CHEMBL276815
Rendered image for CHEMBL276815
CHEMBL370038
Rendered image for CHEMBL370038
CHEMBL13378
Rendered image for CHEMBL13378
CHEMBL370941
Rendered image for CHEMBL370941
CHEMBL372643
Rendered image for CHEMBL372643
SYM2081
Rendered image for SYM2081
CHEMBL1234118
Rendered image for CHEMBL1234118
CHEMBL63861
Rendered image for CHEMBL63861
Protein-Protein Interactions (68)
GRIK5
Tclin
Family:  IC
Novelty:  0.00346213
Score:  0.975
Data Source:  Reactome,STRINGDB
GRIK4
Tclin
Family:  IC
Novelty:  0.0033299
Score:  0.973
Data Source:  Reactome,STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.969
Data Source:  Reactome,STRINGDB
DLG3
Tbio
Novelty:  0.01196565
Score:  0.951
Data Source:  Reactome,STRINGDB
DLG1
Tbio
Novelty:  0.0050926
Score:  0.939
Data Source:  STRINGDB
GRIK2
Tclin
Family:  IC
Novelty:  0.00293615
Score:  0.931
Data Source:  Reactome,STRINGDB
GRIK3
Tclin
Family:  IC
Novelty:  0.01816701
Score:  0.907
Data Source:  Reactome,STRINGDB
NCALD
Tbio
Novelty:  0.03665351
Score:  0.904
Data Source:  STRINGDB
KARS
Tchem
Family:  Enzyme
Novelty:  0.00386511
Score:  0.814
Data Source:  STRINGDB
NETO2
Tbio
Novelty:  0.0414181
Score:  0.67
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Activation of Ca-permeable Kainate Receptor (R-HSA-451308)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Ca-permeable Kainate Receptor
Reactome
Activation of Na-permeable kainate receptors
Reactome
Activation of kainate receptors upon glutamate binding
Reactome
Ionotropic activity of kainate receptors
Reactome
Neuronal System
Name
Explore in Pharos
Explore in Source
Activation of Ca-permeable Kainate Receptor
Activation of Na-permeable kainate receptors
Activation of kainate receptors upon glutamate binding
Ionotropic activity of kainate receptors
Neuronal System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
38.8
Myopia
1
1
0
5.8
26.1
refractive error measurement
1
1
0
5.8
26.1
age at onset
1
1
0
5.8
26.1
risky sexual behaviour measurement
1
1
1
0
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
38.8
Myopia
0
5.8
26.1
refractive error measurement
0
5.8
26.1
age at onset
0
5.8
26.1
risky sexual behaviour measurement
1
0
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor kainate type subunit 1
VGNC:7463
474083
Macaque
glutamate ionotropic receptor kainate type subunit 1
705699
Mouse
MGI:95814
14805
Rat
RGD:2732
29559
Dog
glutamate ionotropic receptor kainate type subunit 1
VGNC:41486
487719
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor kainate type subunit 1
Macaque
glutamate ionotropic receptor kainate type subunit 1
Mouse
Rat
Dog
glutamate ionotropic receptor kainate type subunit 1
Publication Statistics
PubMed Score 363.40
PubMed score by year
PubTator Score 127.40
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Text