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Tbio
GRID1
Glutamate receptor ionotropic, delta-1

Protein Summary
Description
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This gene encodes a subunit of glutamate receptor channels. These channels mediate most of the fast excitatory synaptic transmission in the central nervous system and play key roles in synaptic plasticity.[provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327946
  • ENSP00000330148
  • ENSG00000182771

Symbol
  • KIAA1220
  • GluD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
cellular component
0.91
molecular function
0.79
protein domain
0.73
phenotype
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.48   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.48   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
DEF6
Tbio
Novelty:  0.0378487
p_int:  0.99999479
p_ni:  0.00000521
Score:  0.288
Data Source:  BioPlex,STRINGDB
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.997981417
p_ni:  0.001969736
p_wrong:  0.000048847
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.980216049
p_ni:  0.017704504
p_wrong:  0.002079447
Score:  0.241
Data Source:  BioPlex,STRINGDB
HBB
Tbio
Novelty:  0.00049683
p_int:  0.95621943
p_ni:  0.04378057
Score:  0.165
Data Source:  BioPlex,STRINGDB
CAMK2A
Tchem
Family:  Kinase
Novelty:  0.00534906
Score:  0.796
Data Source:  STRINGDB
DLG2
Tbio
Novelty:  0.00999909
Score:  0.645
Data Source:  STRINGDB
IMMP2L
Tbio
Family:  Enzyme
Novelty:  0.03566408
Score:  0.638
Data Source:  STRINGDB
TET3
Tbio
Family:  Enzyme
Novelty:  0.00557444
Score:  0.632
Data Source:  STRINGDB
GRM2
Tchem
Family:  GPCR
Novelty:  0.00132156
Score:  0.626
Data Source:  STRINGDB
ATAD1
Tbio
Family:  Enzyme
Novelty:  0.06227277
Score:  0.617
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
2
7
82
comparative body size at age 10, self-reported
1
2
2
72.4
2
2
2
58.9
body height
1
1
1
46.5
smoking status measurement
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
7
82
comparative body size at age 10, self-reported
2
72.4
2
58.9
body height
1
46.5
smoking status measurement
1
39.6
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor delta type subunit 1
VGNC:12339
100612556
Macaque
glutamate ionotropic receptor delta type subunit 1
697629
Mouse
MGI:95812
14803
Rat
RGD:68366
79219
Dog
glutamate ionotropic receptor delta type subunit 1
VGNC:51898
489075
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate ionotropic receptor delta type subunit 1
Macaque
glutamate ionotropic receptor delta type subunit 1
Mouse
Rat
Dog
glutamate ionotropic receptor delta type subunit 1
Publication Statistics
PubMed Score 26.48
PubMed score by year
PubTator Score 8.93
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Text