Protein Summary
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple ...more
- ENST00000541091
- ENSP00000446440
- ENSG00000125675
- ENST00000620443
- ENSP00000478489
- ENST00000622768
- ENSP00000481554
- GLUR3
- GLURC
- GLUR3
- GLURC
- GluA3
- MRX94
- GLUR-C
- GLUR-K3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cellular component | 0.81 | ||
molecular function | 0.81 | ||
transcription factor perturbation | 0.74 | ||
protein domain | 0.73 | ||
ligand (chemical) | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 159.03 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 310 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 159.03 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 310 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 17
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 5
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (5)
Active Ligands (17)
Protein-Protein Interactions (157)
GRIA4
Family: IC
Novelty: 0.00284417
p_int: 1
Score: 0.948
Data Source: BioPlex,Reactome,STRINGDB
HECTD4
Family: Enzyme
Novelty: 0.10275533
p_int: 0.999999982
p_ni: 4e-9
p_wrong: 1.4e-8
Score: 0.21
Data Source: BioPlex,STRINGDB
GLRB
Family: IC
Novelty: 0.01721113
p_int: 0.999113019
p_ni: 0.000886937
p_wrong: 4.5e-8
Score: 0.492
Data Source: BioPlex,STRINGDB
CLTCL1
Novelty: 0.05667807
p_int: 0.989431447
p_ni: 0.010568553
Score: 0.194
Data Source: BioPlex,STRINGDB
DNAJB9
Novelty: 0.00536296
p_int: 0.987711075
p_ni: 0.012288925
Score: 0.158
Data Source: BioPlex,STRINGDB
GLB1L2
Family: Enzyme
Novelty: 1.03866932
p_int: 0.956903554
p_ni: 0.043096446
Data Source: BioPlex
SEMA4F
Novelty: 0.00574057
p_int: 0.948245937
p_ni: 0.051754063
Score: 0.177
Data Source: BioPlex,STRINGDB
ALG9
Family: Enzyme
Novelty: 0.02975572
p_int: 0.934310629
p_ni: 0.065689368
p_wrong: 3e-9
Score: 0.18
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (30)
Reactome (11)
KEGG (10)
PathwayCommons (2)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of AMPA receptors | ||||
Reactome | Activation of NMDA receptors and postsynaptic events | ||||
Reactome | Glutamate binding, activation of AMPA receptors and synaptic plasticity | ||||
Reactome | Neuronal System | ||||
Reactome | Neurotransmitter receptors and postsynaptic signal transmission | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of AMPA receptors | ||||
Activation of NMDA receptors and postsynaptic events | ||||
Glutamate binding, activation of AMPA receptors and synaptic plasticity | ||||
Neuronal System | ||||
Neurotransmitter receptors and postsynaptic signal transmission | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (3)
Components (6)
Processes (1)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | ARUK-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | glutamate ionotropic receptor AMPA type subunit 3 | 698396 | ||||||
Mouse | MGI:95810 | 53623 | ||||||
Rat | RGD:70958 | 29628 | ||||||
Dog | glutamate ionotropic receptor AMPA type subunit 3 | VGNC:41482 | 492110 | |||||
Horse | glutamate ionotropic receptor AMPA type subunit 3 | VGNC:18580 | 100055136 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | glutamate ionotropic receptor AMPA type subunit 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | glutamate ionotropic receptor AMPA type subunit 3 | |||||
Horse | glutamate ionotropic receptor AMPA type subunit 3 | |||||
Publication Statistics
PubMed Score 159.03
PubMed score by year
PubTator Score 159.18
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (62)
GeneRif Annotations (31)
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