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Tbio
GREM2
Gremlin-2

Protein Summary
Description
Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells. This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318160
  • ENSP00000318650
  • ENSG00000180875

Symbol
  • CKTSF1B2
  • DAND3
  • PRDC
  • PRDC
  • DAND3
  • STHAG9
  • CKTSF1B2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.69
virus perturbation
0.68
gene perturbation
0.67
histone modification site profile
0.63
tissue
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.48   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.48   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
NACC1
Tbio
Novelty:  0.03367769
p_int:  0.999997884
p_ni:  0.000002116
Data Source:  BioPlex
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.99997008
p_ni:  0.00002992
Data Source:  BioPlex
ZZEF1
Tdark
Novelty:  0.33216648
p_int:  0.999957868
p_ni:  0.000042133
Data Source:  BioPlex
FERMT2
Tbio
Novelty:  0.01020276
p_int:  0.999865355
p_ni:  0.000134621
p_wrong:  2.3e-8
Data Source:  BioPlex
WDHD1
Tbio
Novelty:  0.01511313
p_int:  0.99935448
p_ni:  0.000645511
p_wrong:  9e-9
Data Source:  BioPlex
HECTD3
Tdark
Family:  Enzyme
Novelty:  2.20874654
p_int:  0.999279795
p_ni:  0.000720205
Data Source:  BioPlex
PRKCI
Tchem
Family:  Kinase
Novelty:  0.0076377
p_int:  0.997729002
p_ni:  0.002270998
Data Source:  BioPlex
RNF123
Tbio
Family:  Enzyme
Novelty:  0.01872044
p_int:  0.994757087
p_ni:  0.005242913
Data Source:  BioPlex
DCAF16
Tdark
Novelty:  0.35666992
p_int:  0.99467353
p_ni:  0.002482987
p_wrong:  0.002843484
Data Source:  BioPlex
KBTBD6
Tdark
Novelty:  1.06955768
p_int:  0.99198558
p_ni:  0.00801442
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Signal Transduction (R-HSA-162582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by BMP
Reactome
Signaling by TGF-beta family members
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by BMP
Signaling by TGF-beta family members
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
9
98.8
bone density
2
2
3
71.4
platelet crit
1
1
1
51.7
volumetric bone mineral density
1
1
1
50.6
mean corpuscular hemoglobin concentration
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
9
98.8
bone density
3
71.4
platelet crit
1
51.7
volumetric bone mineral density
1
50.6
mean corpuscular hemoglobin concentration
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1344367
23893
Rat
RGD:1560008
289264
Dog
gremlin 2, DAN family BMP antagonist
VGNC:41475
490367
Horse
gremlin 2, DAN family BMP antagonist
VGNC:18573
100060243
Pig
gremlin 2, DAN family BMP antagonist
100521329
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
gremlin 2, DAN family BMP antagonist
Horse
gremlin 2, DAN family BMP antagonist
Pig
gremlin 2, DAN family BMP antagonist
Publication Statistics
PubMed Score 64.48
PubMed score by year
PubTator Score 13.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title