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Tdark
GREB1L
GREB1-like protein

Protein Summary
Description
Plays a major role in early metanephros and genital development.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269218
  • ENSP00000269218
  • ENSG00000141449
  • ENST00000424526
  • ENSP00000412060
  • ENST00000580732
  • ENSP00000464162

Symbol
  • C18orf6
  • KIAA1772
  • RHDA3
  • C18orf6
  • KIAA1772
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.72
cell type or tissue
0.6
small molecule perturbation
0.58
microRNA
0.48
transcription factor perturbation
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.27   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 9   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.27   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 9   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
TSEN2
Tbio
Family:  Enzyme
Novelty:  0.04151213
p_int:  0.999999832
p_ni:  1.62e-7
p_wrong:  6e-9
Score:  0.282
Data Source:  BioPlex,STRINGDB
TTC9C
Tdark
Novelty:  0.85949913
p_int:  0.990424039
p_ni:  0.000080983
p_wrong:  0.009494978
Data Source:  BioPlex
LYPD4
Tbio
Novelty:  0.00381728
p_int:  0.982253657
p_ni:  0.002561297
p_wrong:  0.015185046
Score:  0.169
Data Source:  BioPlex,STRINGDB
ZMYM6
Tbio
Novelty:  0.4933879
Score:  0.68
Data Source:  STRINGDB
HAPLN3
Tbio
Novelty:  0.19545048
Score:  0.552
Data Source:  STRINGDB
DDX55
Tdark
Family:  Enzyme
Novelty:  0.27887497
Score:  0.551
Data Source:  STRINGDB
TMEM88
Tbio
Novelty:  0.14612337
Score:  0.539
Data Source:  STRINGDB
FAM131B
Tdark
Novelty:  0.3424123
Score:  0.535
Data Source:  STRINGDB
TENM4
Tbio
Novelty:  0.02082032
Score:  0.53
Data Source:  STRINGDB
MFAP2
Tbio
Novelty:  0.01599653
Score:  0.519
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
phosphatidylcholine measurement
1
5
5
75.1
appendicular lean mass
1
1
1
45
serum non-albumin protein measurement
1
1
1
29.8
reticulocyte count
1
1
1
22.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
phosphatidylcholine measurement
5
75.1
appendicular lean mass
1
45
serum non-albumin protein measurement
1
29.8
reticulocyte count
1
22.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth regulation by estrogen in breast cancer 1 like
455328
Mouse
MGI:3576497
381157
Dog
GREB1 like retinoic acid receptor coactivator
VGNC:53615
490524
Cow
GREB1 like retinoic acid receptor coactivator
VGNC:53641
535053
Pig
growth regulation by estrogen in breast cancer 1 like
100524319
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth regulation by estrogen in breast cancer 1 like
Mouse
Dog
GREB1 like retinoic acid receptor coactivator
Cow
GREB1 like retinoic acid receptor coactivator
Pig
growth regulation by estrogen in breast cancer 1 like
Publication Statistics
PubMed Score 25.27
PubMed score by year
PubTator Score 3.08
PubTator score by year
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Related Publications
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PMID
Year
Title