Tchem GRB2 Growth factor receptor-bound protein 2

Protein Summary

Description

Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P62993
• P29354
• Q14450
• Q63057
• Q63059

Gene Name

• GRB2

Ensembl ID

• ENST00000316615
• ENSP00000317360
• ENSG00000177885
• ENST00000316804
• ENSP00000339007
• ENST00000392562
• ENSP00000376345
• ENST00000392563
• ENSP00000376346
• ENST00000392564
• ENSP00000376347
• ENST00000648046
• ENSP00000496913

Symbol

• ASH
• ASH
• Grb3-3
• MST084
• NCKAP2
• MSTP084
• EGFRBP-GRB2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
hub protein	1
interacting protein	1
kinase perturbation	0.98
pathway	0.98

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2933.35   (req: < 5)

Gene RIFs: 160   (req: <= 3)

Antibodies: 633   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2933.35   (req: >= 5)

Gene RIFs: 160   (req: > 3)

Antibodies: 633   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 120

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0