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Tbio
GRAP2
GRB2-related adapter protein 2

Protein Summary
Description
Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc. This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344138
  • ENSP00000339186
  • ENSG00000100351
  • ENST00000407075
  • ENSP00000385607

Symbol
  • GADS
  • GRB2L
  • GRID
  • P38
  • GADS
  • GRID
  • GRPL
  • GrbX
  • Mona
  • GRB2L
  • GRBLG
  • Grf40
  • GRAP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.66
transcription factor
0.64
interacting protein
0.61
tissue
0.6
cell type or tissue
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.46   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 458   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 262.46   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 458   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0