You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GRAMD4
GRAM domain-containing protein 4

Protein Summary
Description
Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53. GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis (Stanelle et al., 2005 [PubMed 15565177]).[supplied by OMIM, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361034
  • ENSP00000354313
  • ENSG00000075240
  • ENST00000406902
  • ENSP00000385689
  • ENST00000408031
  • ENSP00000385851

Symbol
  • DIP
  • KIAA0767
  • DIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.76
kinase perturbation
0.76
transcription factor perturbation
0.68
virus perturbation
0.64
tissue sample
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.08   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.08   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0