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Tbio
GRAMD1A
Protein Aster-A

Protein Summary
Description
Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317991
  • ENSP00000441032
  • ENSG00000089351
  • ENST00000411896
  • ENSP00000439267

Symbol
  • KIAA1533
  • KIAA1533
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.82
transcription factor binding site profile
0.79
histone modification site profile
0.7
PubMedID
0.62
cell type or tissue
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.26   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.26   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
GRAMD2B
Tdark
Novelty:  0.55744753
p_int:  0.999911604
p_ni:  0.000088396
Score:  0.386
Data Source:  BioPlex,STRINGDB
GRAMD1B
Tbio
Novelty:  0.2994102
p_int:  0.999890565
p_ni:  0.000109435
Score:  0.744
Data Source:  BioPlex,STRINGDB
PCDHGB4
Tdark
Novelty:  0.25018904
p_int:  0.999309207
p_ni:  0.000690793
Data Source:  BioPlex
ZNRF4
Tbio
Novelty:  0.16505328
p_int:  0.997732788
p_ni:  0.002267212
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.994040424
p_ni:  0.005959576
Data Source:  BioPlex
TMX1
Tbio
Novelty:  0.03444237
p_int:  0.993758758
p_ni:  0.006241242
Data Source:  BioPlex
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.992184064
p_ni:  0.007815936
Data Source:  BioPlex
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.987498229
p_ni:  0.012501771
Data Source:  BioPlex
TMEM30A
Tbio
Novelty:  0.05115559
p_int:  0.979319055
p_ni:  0.020680945
Data Source:  BioPlex
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.973553998
p_ni:  0.026446002
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
3
8
10
99.4
calcium measurement
1
5
5
97.6
blood protein measurement
2
4
4
96.9
sex hormone-binding globulin measurement
6
2
6
94.7
triglyceride measurement
4
4
5
92
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
10
99.4
calcium measurement
5
97.6
blood protein measurement
4
96.9
sex hormone-binding globulin measurement
6
94.7
triglyceride measurement
5
92
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GRAM domain containing 1A
VGNC:2550
468829
Macaque
GRAM domain containing 1A
718355
Mouse
MGI:105490
52857
Rat
RGD:1311022
361550
Dog
GRAM domain containing 1A
VGNC:41465
484585
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GRAM domain containing 1A
Macaque
GRAM domain containing 1A
Mouse
Rat
Dog
GRAM domain containing 1A
Publication Statistics
PubMed Score 7.26
PubMed score by year
PubTator Score 1.92
PubTator score by year
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Related Publications
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PMID
Year
Title