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Tbio
GPX7
Glutathione peroxidase 7

Protein Summary
Description
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361314
  • ENSP00000354677
  • ENSG00000116157

Symbol
  • GPX6
  • GPX6
  • CL683
  • GPx-7
  • NPGPx
  • GSHPx-7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
histone modification site profile
0.7
PubMedID
0.63
cellular component
0.59
phenotype
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.57   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.57   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (153)
UTP6
Tbio
Novelty:  0.06525007
p_int:  0.999977306
p_ni:  0.000022694
Data Source:  BioPlex
GAK
Tchem
Family:  Kinase
Novelty:  0.00731928
p_int:  0.999968788
p_ni:  0.000031212
Data Source:  BioPlex
PLPBP
Tbio
Family:  Enzyme
Novelty:  0.04352366
p_int:  0.999941832
p_ni:  0.000058166
p_wrong:  2e-9
Score:  0.191
Data Source:  BioPlex,STRINGDB
NFS1
Tbio
Family:  Enzyme
Novelty:  0.01274706
p_int:  0.999832671
p_ni:  0.000167329
Score:  0.178
Data Source:  BioPlex,STRINGDB
ZC3HC1
Tbio
Novelty:  0.089692
p_int:  0.999534765
p_ni:  0.000465235
Data Source:  BioPlex
LYRM4
Tbio
Novelty:  0.03319832
p_int:  0.999478237
p_ni:  0.000016708
p_wrong:  0.000505055
Score:  0.167
Data Source:  BioPlex,STRINGDB
THYN1
Tbio
Novelty:  0.11624704
p_int:  0.999433378
p_ni:  0.00000435
p_wrong:  0.000562272
Score:  0.188
Data Source:  BioPlex,STRINGDB
PHETA1
Tbio
Novelty:  0.52415295
p_int:  0.998449137
p_ni:  0.000006646
p_wrong:  0.001544217
Score:  0.537
Data Source:  BioPlex,STRINGDB
THNSL1
Tdark
Family:  Enzyme
Novelty:  1.98275016
p_int:  0.997820576
p_ni:  0.002179411
p_wrong:  1.3e-8
Data Source:  BioPlex
RIPK1
Tchem
Family:  Kinase
Novelty:  0.00230565
p_int:  0.994999047
p_ni:  0.005000953
Score:  0.201
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
1 – 4 of 4
PTGS2
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
PTGS1
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
ALOX5
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Pathways (37)
Cellular responses to external stimuli (R-HSA-8953897)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutathione peroxidase 7
VGNC:1254
469325
Macaque
glutathione peroxidase 7
715474
Mouse
MGI:1914555
67305
Rat
RGD:1306999
298376
Horse
glutathione peroxidase 7
VGNC:50699
100050590
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutathione peroxidase 7
Macaque
glutathione peroxidase 7
Mouse
Rat
Horse
glutathione peroxidase 7
Publication Statistics
PubMed Score 79.57
PubMed score by year
PubTator Score 18.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title