GPX2
Glutathione peroxidase 2
Protein Summary
Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors. The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active s ...more
- ENST00000389614
- ENSP00000374265
- ENSG00000176153
- GPRP
- GPx-2
- GI-GPx
- GPRP-2
- GPx-GI
- GSHPx-2
- GSHPX-GI
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.94 | ||
PubMedID | 0.92 | ||
small molecule perturbation | 0.89 | ||
disease perturbation | 0.83 | ||
transcription factor perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 208.89 (req: < 5)
Gene RIFs: 29 (req: <= 3)
Antibodies: 178 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 208.89 (req: >= 5)
Gene RIFs: 29 (req: > 3)
Antibodies: 178 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (111)
Nearest Tclin Targets (5)
Upstream (4)
Downstream (1)
1 – 4 of 4
Pathways (35)
Reactome (15)
KEGG (4)
PathwayCommons (3)
WikiPathways (13)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Arachidonic acid metabolism | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Detoxification of Reactive Oxygen Species | ||||
Reactome | Fatty acid metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Arachidonic acid metabolism | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Detoxification of Reactive Oxygen Species | ||||
Fatty acid metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (5)
Functions (2)
Components (2)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 2 | 4 | 4 | 90.5 | |||||
reticulocyte measurement | 3 | 2 | 3 | 90.2 | |||||
mean corpuscular hemoglobin concentration | 2 | 1 | 2 | 88.3 | |||||
reticulocyte count | 2 | 2 | 2 | 86.6 | |||||
mean reticulocyte volume | 1 | 2 | 2 | 84.5 | |||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular volume | 4 | 90.5 | |||||
reticulocyte measurement | 3 | 90.2 | |||||
mean corpuscular hemoglobin concentration | 2 | 88.3 | |||||
reticulocyte count | 2 | 86.6 | |||||
mean reticulocyte volume | 2 | 84.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | glutathione peroxidase 2 | VGNC:12658 | 467483 | |||||
Mouse | MGI:106609 | 14776 | ||||||
Rat | RGD:727780 | 29326 | ||||||
Dog | glutathione peroxidase 2 | VGNC:41462 | 480356 | |||||
Cow | glutathione peroxidase 2 | VGNC:29618 | 533088 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | glutathione peroxidase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | glutathione peroxidase 2 | |||||
Cow | glutathione peroxidase 2 | |||||
Publication Statistics
PubMed Score 208.89
PubMed score by year
PubTator Score 95.86
PubTator score by year
Related Publications
Text Mined References (51)
GeneRif Annotations (29)
Items per page:
0 of 0
PMID | Year | Title |
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