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Tbio
GPX2
Glutathione peroxidase 2

Protein Summary
Description
Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors. The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389614
  • ENSP00000374265
  • ENSG00000176153

Symbol
  • GPRP
  • GPx-2
  • GI-GPx
  • GPRP-2
  • GPx-GI
  • GSHPx-2
  • GSHPX-GI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
PubMedID
0.92
small molecule perturbation
0.89
disease perturbation
0.83
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.89   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.89   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (111)
GSR
Tclin
Family:  Enzyme
Novelty:  0.00040107
Score:  0.986
Data Source:  STRINGDB
SOD2
Tbio
Family:  Enzyme
Novelty:  0.00084288
Score:  0.973
Data Source:  STRINGDB
SOD1
Tchem
Family:  Enzyme
Novelty:  0.00039653
Score:  0.965
Data Source:  STRINGDB
SOD3
Tbio
Family:  Enzyme
Novelty:  0.0015758
Score:  0.963
Data Source:  STRINGDB
GSS
Tbio
Family:  Enzyme
Novelty:  0.03002278
Score:  0.949
Data Source:  STRINGDB
GSTM3
Tbio
Family:  Enzyme
Novelty:  0.0078192
Score:  0.923
Data Source:  STRINGDB
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
Score:  0.917
Data Source:  STRINGDB
GSTA4
Tbio
Family:  Enzyme
Novelty:  0.01099229
Score:  0.892
Data Source:  STRINGDB
CAT
Tbio
Family:  Enzyme
Novelty:  0.00181888
Score:  0.886
Data Source:  STRINGDB
TXNRD1
Tclin
Family:  Enzyme
Novelty:  0.00299018
Score:  0.86
Data Source:  STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
1 – 4 of 4
ALOX5
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
PTGS1
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
PTGS2
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Pathways (35)
Arachidonic acid metabolism (R-HSA-2142753)

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Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Reactome
Fatty acid metabolism
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Fatty acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
2
4
4
90.5
reticulocyte measurement
3
2
3
90.2
mean corpuscular hemoglobin concentration
2
1
2
88.3
reticulocyte count
2
2
2
86.6
mean reticulocyte volume
1
2
2
84.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
90.5
reticulocyte measurement
3
90.2
mean corpuscular hemoglobin concentration
2
88.3
reticulocyte count
2
86.6
mean reticulocyte volume
2
84.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutathione peroxidase 2
VGNC:12658
467483
Mouse
MGI:106609
14776
Rat
RGD:727780
29326
Dog
glutathione peroxidase 2
VGNC:41462
480356
Cow
glutathione peroxidase 2
VGNC:29618
533088
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutathione peroxidase 2
Mouse
Rat
Dog
glutathione peroxidase 2
Cow
glutathione peroxidase 2
Publication Statistics
PubMed Score 208.89
PubMed score by year
PubTator Score 95.86
PubTator score by year
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Related Publications
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PMID
Year
Title