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Tbio
GPT
Alanine aminotransferase 1

Protein Summary
Description
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394955
  • ENSP00000378408
  • ENSG00000167701
  • ENST00000528431
  • ENSP00000433586

Symbol
  • AAT1
  • GPT1
  • AAT1
  • ALT1
  • GPT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.99
disease
0.95
biological term
0.79
gene perturbation
0.7
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26006.5   (req: < 5)
Gene RIFs: 108   (req: <= 3)
Antibodies: 365   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26006.5   (req: >= 5)
Gene RIFs: 108   (req: > 3)
Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (277)
GPT2
Tbio
Family:  Enzyme
Novelty:  0.00478585
p_int:  0.999996993
p_wrong:  0.000003007
Score:  0.81
Data Source:  BioPlex,STRINGDB
GOT1
Tbio
Family:  Enzyme
Novelty:  0.00448817
Score:  0.97
Data Source:  STRINGDB
GOT2
Tbio
Family:  Enzyme
Novelty:  0.00054023
Score:  0.962
Data Source:  STRINGDB
GLUD1
Tbio
Family:  Enzyme
Novelty:  0.00301109
Score:  0.952
Data Source:  STRINGDB
GLUD2
Tbio
Family:  Enzyme
Novelty:  0.01470266
Score:  0.948
Data Source:  STRINGDB
AGXT
Tbio
Family:  Enzyme
Novelty:  0.00267512
Score:  0.927
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.924
Data Source:  STRINGDB
OGDH
Tbio
Family:  Enzyme
Novelty:  0.00674601
Score:  0.921
Data Source:  STRINGDB
NAGS
Tbio
Family:  Enzyme
Novelty:  0.0051524
Score:  0.919
Data Source:  STRINGDB
F2
Tclin
Family:  Enzyme
Novelty:  0.00004833
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Alanine metabolism (R-HSA-8964540)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Alanine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Alanine metabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
8
94.2
mathematical ability
4
4
4
93.4
sex hormone-binding globulin measurement
6
2
6
90.7
self reported educational attainment
5
3
4
5.9
90.6
red blood cell distribution width
2
2
2
83
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
8
94.2
mathematical ability
4
93.4
sex hormone-binding globulin measurement
6
90.7
self reported educational attainment
4
5.9
90.6
red blood cell distribution width
2
83
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamic--pyruvic transaminase
VGNC:12192
472900
Macaque
glutamic--pyruvic transaminase
703122
Mouse
MGI:95802
76282
Rat
RGD:621720
81670
Dog
glutamic--pyruvic transaminase
VGNC:41460
609914
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamic--pyruvic transaminase
Macaque
glutamic--pyruvic transaminase
Mouse
Rat
Dog
glutamic--pyruvic transaminase
Publication Statistics
PubMed Score 26006.50
PubMed score by year
PubTator Score 7779.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title