GPT
Alanine aminotransferase 1
Protein Summary
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity). This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]
- ENST00000394955
- ENSP00000378408
- ENSG00000167701
- ENST00000528431
- ENSP00000433586
- AAT1
- GPT1
- AAT1
- ALT1
- GPT1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 0.99 | ||
disease | 0.95 | ||
biological term | 0.79 | ||
gene perturbation | 0.7 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26006.5 (req: < 5)
Gene RIFs: 108 (req: <= 3)
Antibodies: 365 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26006.5 (req: >= 5)
Gene RIFs: 108 (req: > 3)
Antibodies: 365 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (277)
GPT2
Family: Enzyme
Novelty: 0.00478585
p_int: 0.999996993
p_wrong: 0.000003007
Score: 0.81
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (19)
Reactome (3)
KEGG (6)
PathwayCommons (5)
UniProt (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Alanine metabolism | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Alanine metabolism | ||||
Metabolism | ||||
Metabolism of amino acids and derivatives | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (2)
Components (2)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 2 | 2 | 1 | 8 | 94.2 | ||||
mathematical ability | 4 | 4 | 4 | 93.4 | |||||
sex hormone-binding globulin measurement | 6 | 2 | 6 | 90.7 | |||||
self reported educational attainment | 5 | 3 | 4 | 5.9 | 90.6 | ||||
red blood cell distribution width | 2 | 2 | 2 | 83 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
alkaline phosphatase measurement | 1 | 8 | 94.2 | ||||
mathematical ability | 4 | 93.4 | |||||
sex hormone-binding globulin measurement | 6 | 90.7 | |||||
self reported educational attainment | 4 | 5.9 | 90.6 | ||||
red blood cell distribution width | 2 | 83 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | glutamic--pyruvic transaminase | VGNC:12192 | 472900 | |||||
Macaque | glutamic--pyruvic transaminase | 703122 | ||||||
Mouse | MGI:95802 | 76282 | ||||||
Rat | RGD:621720 | 81670 | ||||||
Dog | glutamic--pyruvic transaminase | VGNC:41460 | 609914 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | glutamic--pyruvic transaminase | |||||
Macaque | glutamic--pyruvic transaminase | |||||
Mouse | ||||||
Rat | ||||||
Dog | glutamic--pyruvic transaminase | |||||
Publication Statistics
PubMed Score 26006.50
PubMed score by year
PubTator Score 7779.87
PubTator score by year
Related Publications
Text Mined References (124)
GeneRif Annotations (108)
Items per page:
0 of 0
PMID | Year | Title |
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